Results 151 to 160 of about 3,743,687 (283)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The private solution trap in collective action problems across 34 nations. [PDF]

Proc Natl Acad Sci U S A
Malthouse E, Pilgrim C, Sgroi D, Accerenzi M, Alfonso A, Ashraf RU, Baard M, Banerjee S, Belianin A, Bhattacharjee S, Bhattacharya M, Brañas-Garza P, Cárdenas JC, Carriquiry M, Choi S, Clochard GJ, Denzon EE, Dessoulavy-Sliwinski B, Dini G, Dong L, Ertl A, Exadaktylos F, Filiz-Ozbay E, Flecke SL, Galeotti F, Garcia-Muñoz T, Hanaki N, Hollard G, Horn D, Huang L, İriş D, Kiss HJ, Koch J, Kovářík J, Kwarteng OKB, Lange A, Leites M, Leung TH, Lim W, Morren M, Nockur L, Okyere CY, Oudah M, Ozkes AI, Page L, Park J, Pfattheicher S, Proestakis A, Ramos C, Ramos-Sosa M, Ashraf MS, Sanjaya MR, Schwaiger R, Sene O, Song F, Spycher S, Staněk R, Tanchingco N, Tavoni A, Te Velde V, Vázquez-De Francisco MJ, Visser M, Wang JT, Wang W, Weng WC, Werner K, Wijayanti A, Winkler R, Wooders J, Ying L, Zhen W, Hills T.   +71 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A second-order dynamical system for solving inverse quasi-variational inequalities and its application. [PDF]

PLoS One
Gan T, Khan VK, Ahmad MK, Cai QB.
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Climatic changes: Global causes, global consequences, global solution

, 2013
Ključni uzrok klimatskih promena u savremenosti nalazi se u karakteristici kapitalizma koji počiva na ideji o maksimalizaciji profita. Dakle, radi se o sistemskoj karakteristici.Trka za zaradom bez obzira na posledice po prirodu, uspesi ubrzane industrijalizacije, nastojanje čoveka da ostvaruje sve nove i nove potrebe koje mu se rađaju (od upotrebe ...
Šuvaković, Uroš, Nadić, Darko P.
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Hybrid optimization algorithm for solving path planning problems based on grey wolf optimization algorithm. [PDF]

Sci Rep
Cheng G, Liu Y.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Existence of global weak solutions for a p-Laplacian inequality with strong dissipation in noncylindrical domains

Electronic Journal of Differential Equations, 2022
Jorge Ferreira, Erhan Piskin, Mohammad Shahrouzi, Sebastiao Cordeiro, Carlos Alberto Raposo   +4 more
doaj