Results 31 to 40 of about 74,517 (259)

Globins in Caenorhabditis elegans

IUBMB Life, 2011
AbstractExtensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C.
Tilleman, L, Germani, F, De Henau, S, Geuens, E, Hoogewijs, D, Braeckman, B P, Vanfleteren, J R, Moens, L, Dewilde, S   +8 more
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Cotranslational Folding of Globin [PDF]

Journal of Biological Chemistry, 1997
Globin synthesis in a wheat germ cell-free translation system was performed in the presence of [3H]hemin and [35S]methionine to determine the minimal length of the nascent ribosome-bound globin chain capable of heme binding. Nascent polypeptides of predetermined size were synthesized on ribosomes by translation of truncated mRNA molecules.
Anton A. Komar, Igor A. Krasheninnikov, Alexander S. Spirin, Aigar Kommer   +3 more
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Globin genes on the move [PDF]

Journal of Biology, 2008
Recent data published in BMC Biology from the globin gene clusters in platypus, together with data from other species, show that beta-globin genes transposed from one chromosomal location to another. This resolves some controversies about vertebrate globin gene evolution but ignites new ones.
openaire   +3 more sources

Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals

BMC Biology, 2008
Background Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were ...
Warren Wesley C, Graves Tina, Fulton Bob, Deakin Janine E, Cooper Steven JB, Patel Vidushi S, Wilson Richard K, Graves Jennifer AM   +7 more
doaj   +1 more source

Reactivation of a developmentally silenced embryonic globin gene

Nature Communications, 2021
Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super ...
Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs   +25 more
doaj   +1 more source

Oxygen Channels and Fractal Wave-Particle Duality in the Evolution of Myoglobin and Neuroglobin [PDF]

, 2016
The evolution of terrestrial and aquatic wild type (WT) globins is dominated by changes in two proximate - distal Histidine ligand exit channels, here monitored quantitatively by hydropathic waves. These waves reveal allometric functional features inaccessible to single amino acid stereochemical contact models, and even very large all-atom Newtonian ...
arxiv   +1 more source

A Dirichlet process mixture of hidden Markov models for protein structure prediction [PDF]

Annals of Applied Statistics 2010, Vol. 4, No. 2, 916-942, 2010
By providing new insights into the distribution of a protein's torsion angles, recent statistical models for this data have pointed the way to more efficient methods for protein structure prediction. Most current approaches have concentrated on bivariate models at a single sequence position.
arxiv   +1 more source

Globin and Globin Gene Structure of the Nerve Myoglobin of Aphrodite aculeata [PDF]

Journal of Biological Chemistry, 1996
The globin of the nerve cord of the polychaete annelid Aphrodite aculeata was isolated and purified to homogeneity. The native molecule has a pI of 6.3 and acts as a dimer of two identical Mr 15, 644.5 polypeptide chains as determined by electrospray mass spectrometry.
Dewilde, Sylvia, Blaxter, Mark, van Hauwaert, Marie-Louise, Vanfleteren, Jacques, Esmans, Edgard, Marden, Mike, Griffon, Nathalie, Moens, Luc   +7 more
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Formation of the Native Topology of a Protein is due to the “Conserved but Non-Functional” Residues: A Case of Apomyoglobin Folding

Frontiers in Bioscience-Landmark
This paper is dedicated to the memory of Oleg B. Ptitsyn (1929-1999) and presents an answer to his question: “What is the role of conserved non-functional residues in protein folding?”. This answer follows from the experimental works of three labs.
Valentina E. Bychkova, Dmitry A. Dolgikh, Vitalii A. Balobanov, Alexei V. Finkelstein   +3 more
doaj   +1 more source

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. [PDF]

PLoS ONE, 2016
In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-
Divya S Vinjamur, Yousef N Alhashem, Safa F Mohamad, Parth Amin, David C Williams, Joyce A Lloyd   +5 more
doaj   +1 more source