Results 81 to 90 of about 151,779 (318)
Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]
, 1952 The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. [PDF]
, 2018 Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance.
Han, Tianxu +10 more
core +2 more sources
Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs [PDF]
Blood, 1997 Abstract We have examined the pattern of human globin gene switching in transgenic mice containing three different γ and β gene constructs (HS2GγAγδβ, HS2Aγβneo, and HS2Aγenβ) and compared the results with previously described transgenics (HS2Aγβ, HS2GγAγ-117δβ, and LCRεGγAγδβ).
N A, Roberts +4 more
openaire +2 more sources
A pH Dependant Switch in DHP Oxidation Mechanism [PDF]
, 2017 Dehaloperoxidase (DHP) is a multifunctional enzyme found in Amphitrite ornata, a sediment-dwelling marine worm. This enzyme possess the structure of a traditional hemoglobin enzyme and serves as the primary oxygen carrier in A.
Fehr, Travis
core +1 more source
Biotechnology Progress, EarlyView.Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan +4 more
wiley +1 more source
Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion. [PDF]
PLoS ONE, 2014 BackgroundThe molecular profile of circulating blood can reflect physiological and pathological events occurring in other tissues and organs of the body and delivers a comprehensive view of the status of the immune system.
Heesun Shin +10 more
doaj +1 more source
A Novel Alpha1-Variant (HBA1:c.-35T>C) Complexed With the First Reported Hb M-Saskatoon in the Chinese Population. [PDF]
Mol Genet Genomic MedThe research subjects were diagnosed with two distinct types of abnormal hemoglobin. Our study reports the first case of a complex hemoglobinopathy in China, characterized by the presence of the globally first‐reported alpha1 variant (HBA1:c.‐35T>C) and the initial identification of Hb M‐Saskatoon (HBB:c.190C>T) in China.
Yang Y +5 more
europepmc +2 more sources
Conformational studies of various hemoglobins by natural-abundance 13C NMR spectroscopy [PDF]
, 1972 Studies of variously liganded hemoglobins (both from human and rabbit) by natural-abundance 13C NMR spectroscopy have revealed apparent conformational differences that have been interpreted on the basis of two quaternary structures for the α2ß2 tetramer,
Moon, R. B., Richards, J. H.
core +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Human globin ψB2is not a globin-related sequence [PDF]
Nucleic Acids Research, 1982 We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
S H, Shen, O, Smithies
openaire +2 more sources