Results 121 to 130 of about 17,498 (250)
Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence [PDF]
Xiaoxin Xu, Xin Hong, Wang Gan
openalex +1 more source
Sturgeons: An Evolutionary Insight to The α-globin Protein Speciation and Diversification [PDF]
Shohreh Ariaeenejad +4 more
openalex +1 more source
Direct air capture (DAC) of carbon dioxide (CO2) emerges as a key strategy for climate crisis mitigation. Redox‐mediated electrochemical carbon capture offers a promising route for energy‐efficient DAC. This perspective discusses recent advances in the field, highlighting key challenges, such as oxygen interference at low CO2 concentrations, and ...
Tilmann J. Neubert, Martin Oschatz
wiley +1 more source
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm +3 more
wiley +1 more source
ABSTRACT Administration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD). The objectives of the 1‐year dose‐escalation Phase IIa/IIb Memantine trial (MeMAGEN – NCT 03247218) with 17 SCD patients who were under stable ...
Ariel Koren +7 more
wiley +1 more source
Comparison of Evolutionary Relationships between Branchiostoma floridae, Ciona intestinalis, and Homo sapiens Globins Provide Evidence of Gene Co-Option and Convergent Evolution. [PDF]
Yano N +4 more
europepmc +1 more source
Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss +3 more
wiley +1 more source
A Rational Approach to Pharmacotherapy in Pregnancy
Abstract Most pregnant individuals are exposed to at least one medication, whether prescription or over the counter, during pregnancy. Despite the ubiquity of medication use in pregnancy, there remains no standardized framework to guide clinicians in selecting the most appropriate pharmacotherapy that balances maternal needs with fetal safety. This gap
Gregory W. Kirschen +2 more
wiley +1 more source

