Results 131 to 140 of about 8,559 (239)

Maximum likelihood tree of several globins from D. rerio, Trichoplax and the sea urchin.

, 2012
Globins from D. rerio, Trichoplax and the sea urchin are highlighted in blue, red and green, respectively. Only one globin domain of the polymeric globin from the sea urchin was used for tree reconstruction.
Amit Pande (125780), Jasmin Dröge (125776), Wojciech Makałowski (5913), Ella W. Englander (125785)   +3 more
core   +1 more source

A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.
ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger, Nicolas Hebert, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Sandia Adypagavane, Meghan Perkins, Laura Matabishi‐Bibi, France Pirenne, Claire Berquet, Stephane Moutereau, Serge Pissard, Frédéric Galactéros, Michael C. Marden, Pablo Bartolucci   +14 more
wiley   +1 more source

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1719-1724, July 2026.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi, Bhavi P. Modi, Phillip A. Richmond, Massimo Mangino, Loryn Byres, Cassie McDonald, Joshua Dalmann, Simran Samra, Kate L. Del Bel, Anna Lehman, Jessica L. Zambonin, Stuart E. Turvey   +11 more
wiley   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Paracetamol may improve renal function in patients with severe Plasmodium knowlesi malaria, particularly in those with acute kidney injury and hemolysis, via inhibition of cell‐free hemoglobin mediated oxidative kidney damage. We developed a population pharmacokinetic/pharmacodynamic (PK/PD) model to assess effects of paracetamol on creatinine,
Thanaporn Wattanakul, Daniel J. Cooper, Katherine Plewes, Matthew J. Grigg, Giri S. Rajahram, Timothy William, Arjen M. Dondorp, Michael D. Edstein, Geoffrey W. Birrell, Nicholas M. Anstey, Richard M. Hoglund, Bridget E. Barber, Joel Tarning   +12 more
wiley   +1 more source

Complete Amino Acid Sequences of the Major Early Embryonic α-Like Globins of the Chicken

, 1980
Vertebrate embryos contain hemoglobins composed of globin polypeptides structurally distinct from those of adults. Together with fetal and adult globin chains, these early embryonic globins are encoded by two developmentally regulated multigene families.
Hood, Leroy E., Tobin, Allan J., Chapman, Barbara S.   +2 more
core  

Determination of ligand pathways in globins apolar tunnels versus polar gates

, 2012
: Although molecular dynamics simulations suggest multiple interior pathways for O-2 entry into and exit from globins, most experiments indicate well defined single pathways.
M. Bolognesi, Dewilde, Sylvia, Soman, Jayashree, M. Nardini, Olson, John S., Blouin G. C., Olson J. S., Singleton, Eileen W., Pesce, Alessandra, Dewilde S., E. W. Singleton, Singleton E. W., Bolognesi M., Salter M. D., G. C. Blouin, Bolognesi, Martino, Nardini M., L. Moens, Blouin, George C., J. S. Olson, A. Pesce, Moens L., M. D. Salter, Nardini, Marco, Singleton, Eileen Willey, J. Soman, S. Dewilde, Soman J., Salter, Mallory D., Moens, Luc   +29 more
core   +1 more source

Longitudinal Analysis of Sleep‐Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia

Clinical Otolaryngology, Volume 51, Issue 4, Page 520-528, July 2026.
ABSTRACT Objectives Sleep‐disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.
Shifa Hamdule, Melanie Koelbel, Johanna C. Gavlak, Sati Sahota, Fenella J. Kirkham, Anna M. Hood   +5 more
wiley   +1 more source

Patient‐Reported Outcomes With Luspatercept Through 5 Years of Treatment in Patients With Non‐Transfusion‐Dependent β‐Thalassemia Treated in the BEYOND Trial

European Journal of Haematology, Volume 117, Issue 1, Page 161-173, July 2026.
ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam, Maria Domenica Cappellini, Antonis Kattamis, Matthew Dyer, Ahmed Hnoosh, Laurie Eliason, Christopher G. Pelligra, Shien Guo, Yutian Mu, Loyse Felber Medlin, Marta Reverte, Kevin H. M. Kuo, Ali T. Taher   +12 more
wiley   +1 more source

The osmotic pressure of globin [PDF]

Biochemical Journal, 1932
J, Roche, A, Roche, G S, Adair, M E, Adair   +3 more
openaire   +2 more sources

Compound Heterozygosity for Hemoglobin S and Hemoglobin LuLu Island

American Journal of Hematology, Volume 101, Issue 7, Page 1440-1442, July 2026.
Dana Lewis, Thomas Lofaro, Laura Fraser, Sheana Wijemanne, Barbara J. Bain   +4 more
wiley   +1 more source