Results 121 to 130 of about 45,771 (276)
Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite
MoleculesNonsymbiotic phytoglobins (nsHbs) are a diverse superfamily of hemoproteins grouped into three different classes (1, 2, and 3) based on their sequences.
Cezara Zagrean-Tuza +4 more
doaj +1 more source
The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, and Counseling [PDF]
, 1977 In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia.
Cooper, Florence N., Scott, Robert B.
core +1 more source
Conformational studies of various hemoglobins by natural-abundance 13C NMR spectroscopy [PDF]
, 1972 Studies of variously liganded hemoglobins (both from human and rabbit) by natural-abundance 13C NMR spectroscopy have revealed apparent conformational differences that have been interpreted on the basis of two quaternary structures for the α2ß2 tetramer,
Moon, R. B., Richards, J. H.
core +1 more source
A comparison of the heme binding pocket in globins and cytochrome b5.
Journal of Biological Chemistry, 1975 Of the 85 three-dimensionally characterized residues of cytochrome b5, 51 are found to be structurally and topologically equivalent to the globin fold. When these proteins have been superimposed, the heme irons are found to be less than 1.4 A separated ...
M. Rossmann, P. Argos
semanticscholar +1 more source
European Journal of Haematology, EarlyView.ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam +12 more
wiley +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
The FEBS Journal, EarlyView.AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source
Transfusion, EarlyView.Abstract Background ABO‐incompatible (ABOi) hematopoietic stem cell transplantation (HSCT) is often associated with ABO discrepancies post‐HSCT. Re‐emergence of the patient's original type post‐HSCT may signal graft loss, disease relapse, recent transfusion, or soluble ABO antigen.
Sheri Hugan, Nada Naiyer, Laura Cooling
wiley +1 more source
The DNA binding factor Hmg20b is a repressor of erythroid differentiation
Haematologica, 2011 Background In erythroblasts, the CoREST repressor complex is recruited to target promoters by the transcription factor Gfi1b, leading to repression of genes mainly involved in erythroid differentiation.
Fatemehsadat Esteghamat +13 more
doaj +1 more source