Results 101 to 110 of about 45,771 (276)
Gasotransmitters, poisons, and antimicrobials: it's a gas, gas, gas! [PDF]
, 2013 We review recent examples of the burgeoning literature on three gases that have major impacts in biology and microbiology. NO, CO and H2S are now co-classified as endogenous gasotransmitters with profound effects on mammalian physiology and, potentially,
Jesse, H.E. +2 more
core +1 more source
Human globin ψB2is not a globin-related sequence [PDF]
Nucleic Acids Research, 1982 We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
S H, Shen, O, Smithies
openaire +2 more sources
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Pattern of cavities in globins: The case of human hemoglobin
Biopolymers, 2009 Our aim is to shed light on the conservation of potential ligand docking sites that play an important role in ligand dynamics of globins by using the technique of filling internal cavities naturally present in hemoglobin and myoglobin with xenon atoms ...
C. Savino +6 more
semanticscholar +1 more source
Compound Heterozygosity for Hemoglobin S and Hemoglobin LuLu Island
American Journal of Hematology, EarlyView.
Dana Lewis +4 more
wiley +1 more source
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008 Background and Objectives Thalassaemia is one of the most common single gene disorders, which is most prevalent in the Mediterranean, the Middle East, Indian subcontinent (malaria belt). One of the mutations that result in Thalassaemia is the deletion in
R R Alimohammadi +10 more
doaj
Canalization of globins in the adaptive evolution of birds
Avian ResearchThe globin superfamily, central to oxygen (O2) cascade dynamics, exemplifies how canalization—evolutionary stabilization of phenotypic traits—enables vertebrates to thrive in extreme environments.
Xiaojia Zhu +7 more
doaj +1 more source
The adaptive evolution of polar fishes: Structure, function and molecular phylogeny of hemoglobin [PDF]
, 2006 emperature affects all molecular processes and is the major determinant of habitat suitability. Whilst there is an increasing understanding of evolutionary adaptation to temperature in some processes, several key questions often remain open about the ...
Di Prisco, Guido, Verde, Cinzia
core +1 more source
The role of iron in normal and impaired testicular function
Andrology, EarlyView.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source