Results 101 to 110 of about 8,559 (239)

Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin SC disease: A real‐world study in Quebec

British Journal of Haematology, EarlyView.
Summary Haemoglobin SC (HbSC) disease is the second most prevalent form of sickle cell disease, but evidence for hydroxyurea (hydroxycarbamide; HU) to prevent pain episodes was limited until the prospective identification of variables as outcomes for treatment (PIVOT) trial.
Alice Girard, Laurianne Charette, Mélissa Haouchine, Laurence Bozec, Mohamed Zakaria Bachir Bouyadjera, Mariane Poitras, Vincent‐Thierry Taillefer, Chloé Trudeau, Yves Pastore, Nathalie Letarte, Stéphanie Forté   +10 more
wiley   +1 more source

Nitric Oxide Reactivity with Globins as Investigated Through Computer Simulation [PDF]

, 2008
This chapter reviews the application of classical and quantum-mechanical atomistic simulation tools used in the investigation of several relevant issues in nitric oxide reactivity with globins and presents different simulation strategies based on ...
F. Javier Luque, Crespo, Alejandro, Marcelo A. Marti, Capece, Luciana, Axel Bidon‐Chanal, Marti, Marcelo A., Estrin, Dario Ariel, Bidon Chanal, Axel, Guallar, Victor, Alejandro Crespo, Dario A. Estrin, Luque, F. Javier, Victor Guallar, Luciana Capece   +13 more
core   +1 more source

The DNA binding factor Hmg20b is a repressor of erythroid differentiation

Haematologica, 2011
Background In erythroblasts, the CoREST repressor complex is recruited to target promoters by the transcription factor Gfi1b, leading to repression of genes mainly involved in erythroid differentiation.
Fatemehsadat Esteghamat, Thamar Bryn van Dijk, Harald Braun, Sylvia Dekker, Reinier van der Linden, Jun Hou, Pavlos Fanis, Jeroen Demmers, Wilfred van IJcken, Zeliha Özgür, Rastislav Horos, Farzin Pourfarzad, Marieke von Lindern, Sjaak Philipsen   +13 more
doaj   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

British Journal of Haematology, EarlyView.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source

Nitrogen hyperfine and nuclear quadrupole components derived from the simulations for GLB-26 in comparison to other globins.

, 2013
Nitrogen hyperfine and nuclear quadrupole components derived from the simulations for GLB-26 in comparison to other globins.
Bart P. Braeckman (294301), Sylvia Dewilde (40053), Jean-Pierre Timmermans (209393), Luc Moens (40055), Nora Nagy (294299), Isabel Pintelon (294300), Sabine Van Doorslaer (175514), Dirk Adriaensen (294304), Martje Pauwels (294297), Lesley Tilleman (175502), Sasha De Henau (294294), Karolien De Wael (294302)   +11 more
core   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Nitrite binding to globins: linkage isomerism, EPR silence and reductive chemistry

, 2014
The nitrite adducts of globins can potentially bind via O- or N- linkage to the heme iron. We have used EPR (electron paramagnetic resonance) and DFT (density functional theory) to explore these binding modes to myoglobin and hemoglobin.
Svistunenko, DA, Cioloboc, Daniela, Bischin, Cristina, Scurtu, Florina, Silaghi-Dumitrescu, Radu, Svistunenko, Dimitri A., Silaghi-Dumitrescu, R, Cooper, Chris E., Cooper, CE, Bischin, C, Scurtu, F, Cioloboc, D   +11 more
core   +1 more source

Study of invertebrate and plant globins : templates and evolutionary trees

, 1992
Globin molecules have a very conservative secondary and tertiary structure, whereas their amino acid sequences are rather variable. To determine the residue restrictions imposed on certain sites of the sequence of non-vertebrate globins (i.e ...
Van de Peer, YvesWE098010013230950000-0003-4327-3730F5A2BFFE-F0ED-11E1-A9DE-61C894A0A6B4, Peeters, K, Van de Peer, Yves, De Baere, Raymond, Winnepenninckx, Birgitta, Moens, Luc   +5 more
core  

Globins in nonvertebrate species: dispersal by horizontal gene transfer and evolution of the structure-function relationships

, 1996
Using a new template based on an alignment of 145 nonvertebrate globins we examined several recently determined sequences of putative globins and globin-like hemeproteins. We propose that all globins have evolved from a family of ancestral, approx.
Kapp, Oscar, Vanfleteren, J., J. Vanfleteren, K. Peeters, Vanfleteren, Jacques, Vinogradov, S.N., J. Czeluzniak, Goodman, M., Vinogradov, Serge, O. Kapp, M. Goodman, Van de Peer, Yves, S. Vinogradov, Blaxter, Mark, Czelusniak, J., Y. Van de Peer, Goodman, Morris, Kapp, O., Czeluzniak, John, L. Moens, Moens, Luc, Peeters, Kris, M. Blaxter   +22 more
core   +1 more source

What influences Hb fetal production in adulthood?

Revista Brasileira de Hematologia e Hemoterapia, 2011
Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini, Paula Juliana Antoniazzo Zamaro, Claudia Regina Bonini-Domingos   +2 more
doaj   +1 more source