Results 111 to 120 of about 9,131 (243)

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG‐4592)

Cell Proliferation, EarlyView.
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang, Jiahui Wu, Xinbing Guo, Wenchen Shen, Xiao Sang, Xiuli Gong, Shu‐Zhen Huang, Jingzhi Zhang, Fanyi Zeng   +8 more
wiley   +1 more source

The DNA binding factor Hmg20b is a repressor of erythroid differentiation

Haematologica, 2011
Background In erythroblasts, the CoREST repressor complex is recruited to target promoters by the transcription factor Gfi1b, leading to repression of genes mainly involved in erythroid differentiation.
Fatemehsadat Esteghamat, Thamar Bryn van Dijk, Harald Braun, Sylvia Dekker, Reinier van der Linden, Jun Hou, Pavlos Fanis, Jeroen Demmers, Wilfred van IJcken, Zeliha Özgür, Rastislav Horos, Farzin Pourfarzad, Marieke von Lindern, Sjaak Philipsen   +13 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Three globin lineages belonging to two structural classes in genomes from the three kingdoms of life

, 2005
Although most globins, including the N-terminal domains within chimeric proteins such as flavohemoglobins and globin-coupled sensors, exhibit a 3/3 helical sandwich structure, many bacterial, plant, and ciliate globins have a 2/2 helical sandwich ...
Arrendondo-Peter, R., Gough, J., Vinogradov, S. N., Hoogewijs, D., Dewilde, S., Guertin, M., Moens, L., Vanfleteren, J. R., Bailly, X.   +8 more
core   +2 more sources

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Maximum likelihood tree of several globins from D. rerio, Trichoplax and the sea urchin.

, 2012
Globins from D. rerio, Trichoplax and the sea urchin are highlighted in blue, red and green, respectively. Only one globin domain of the polymeric globin from the sea urchin was used for tree reconstruction.
Amit Pande (125780), Jasmin Dröge (125776), Wojciech Makałowski (5913), Ella W. Englander (125785)   +3 more
core   +1 more source

Adaptation to extreme environments: A review of Antarctic fish physiology

Journal of Fish Biology, EarlyView.
Abstract Having evolved in the chronically cold and thermally stable waters of the Southern Ocean (SO) for millions of years, Antarctic fish possess a suite of physiological specializations that enable them to survive at temperatures near the freezing point of seawater. Adaptations include the evolution of antifreeze proteins, modifications of membrane
Seungyeon Lee, Sachithra Amarin Hettiarachchi, Il‐Chan Kim, Jae‐Seong Lee, Thomas Desvignes, Julia M. York, Laura Ghigliotti, Jilda Alicia Caccavo, Jin‐Hyoung Kim   +8 more
wiley   +1 more source

What influences Hb fetal production in adulthood?

Revista Brasileira de Hematologia e Hemoterapia, 2011
Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini, Paula Juliana Antoniazzo Zamaro, Claudia Regina Bonini-Domingos   +2 more
doaj   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source