Protection by neuroglobin expression in brain pathologies [PDF]
Frontiers in Neurology, 2016 Astrocytes play an important role in physiological, metabolic and structural functions and, when impaired, they can be involved in various pathologies including Alzheimer, focal ischemic stroke and traumatic brain injury.
Eliana Baez +5 more
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The Anti-Apoptotic Role of Neuroglobin [PDF]
Cells, 2012 The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of ...
Thomas Brittain
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Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells [PDF]
Biomolecules, 2023 Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to ...
Marina A. Semenova +3 more
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Engineering neuroglobin nitrite reductase activity based on myoglobin models [PDF]
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
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Repurposing of Tibolone in Alzheimer’s Disease [PDF]
Biomolecules, 2023 Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition.
George E. Barreto
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Neuroglobin: A promising candidate to treat neurological diseases [PDF]
Neural Regeneration ResearchNeurodevelopmental and neurodegenerative illnesses constitute a global health issue and a foremost economic burden since they are a large cause of incapacity and death worldwide. Altogether, the burden of neurological disorders has increased considerably
Ivan Millan Yañez +2 more
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Insights into the Function of a Conserved Cys120 in Human Neuroglobin in Oxidative Stress Regulation of Breast Cancer Cells [PDF]
BiomoleculesHuman neuroglobin (Ngb) is a globin featuring a disulfide bond (Cys46–Cys55) and a redox-active cysteine residue (Cys120) and plays a dual role in cellular stress responses. In this study, we investigated how wild-type (WT) Ngb and its two mutants, C120S
Shu-Qin Gao +4 more
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Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
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Neuroglobin, clues to function and mechanism
Molecular Aspects of Medicine, 2022 pre proof of review published on Molecular Aspects of Medicine Volume 84 article number ...
Cécile Exertier +2 more
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Neuroglobin and cytoglobin: two new members of globin family [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui +1 more
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