Engineering neuroglobin nitrite reductase activity based on myoglobin models [PDF]
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
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The Anti-Apoptotic Role of Neuroglobin
Cells, 2012 The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of ...
Thomas Brittain
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Neuroglobin in rat brain neurons [PDF]
Сибирский научный медицинский журнал, 2021 Neuroglobin is a metalloprotein expressed predominantly in a nervous system and involved in the functioning of cells in normal and pathological conditions. Despite numerous studies, information on its regional distribution is ambiguous.
E. V. Uzlova, S. M. Zimatkin
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Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells [PDF]
Biomolecules, 2023 Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to ...
Marina A. Semenova +3 more
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Investigating the role of neuroglobin in cholesterol metabolism: a spotlight on brain-derived cells [PDF]
Lipids in Health and DiseaseBackground Cholesterol is a crucial determinant of membrane structure, signaling, and synaptic function in the central nervous system, where its homeostasis is tightly controlled to support neuronal viability and plasticity to prevent neurodegeneration ...
Sara Caputo +6 more
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Repurposing of Tibolone in Alzheimer’s Disease [PDF]
Biomolecules, 2023 Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition.
George E. Barreto
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Insights into the Function of a Conserved Cys120 in Human Neuroglobin in Oxidative Stress Regulation of Breast Cancer Cells [PDF]
BiomoleculesHuman neuroglobin (Ngb) is a globin featuring a disulfide bond (Cys46–Cys55) and a redox-active cysteine residue (Cys120) and plays a dual role in cellular stress responses. In this study, we investigated how wild-type (WT) Ngb and its two mutants, C120S
Shu-Qin Gao +4 more
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Neuroglobin: A promising candidate to treat neurological diseases [PDF]
Neural Regeneration ResearchNeurodevelopmental and neurodegenerative illnesses constitute a global health issue and a foremost economic burden since they are a large cause of incapacity and death worldwide. Altogether, the burden of neurological disorders has increased considerably
Ivan Millan Yañez +2 more
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Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
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Neuroglobin-enriched secretome provides neuroprotection against hydrogen peroxide and mitochondrial toxin-induced cellular stress [PDF]
Cell StressAberrant response to physiological cell stress is part of the mechanisms underlying the development of diverse human diseases, including neuropathologies.
Giovanna Bastari +5 more
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