The Anti-Apoptotic Role of Neuroglobin [PDF]
Cells, 2012 The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of ...
Thomas Brittain
exaly +5 more sources
Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells [PDF]
Biomolecules, 2023 Neuroglobin, which is a heme protein from the globin family that is predominantly expressed in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms underlying the neuroprotective function of Ngb remain poorly understood to ...
Marina A. Semenova +3 more
doaj +2 more sources
Engineering neuroglobin nitrite reductase activity based on myoglobin models [PDF]
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
doaj +2 more sources
Repurposing of Tibolone in Alzheimer’s Disease [PDF]
Biomolecules, 2023 Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterised by the accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory and cognition.
George E. Barreto
doaj +2 more sources
Adaptations to hypoxia in the vertebrate retina. [PDF]
J PhysiolAbstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Jonz MG.
europepmc +2 more sources
Neuroglobin: A promising candidate to treat neurological diseases [PDF]
Neural Regeneration ResearchNeurodevelopmental and neurodegenerative illnesses constitute a global health issue and a foremost economic burden since they are a large cause of incapacity and death worldwide. Altogether, the burden of neurological disorders has increased considerably
Ivan Millan Yañez +2 more
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Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin. [PDF]
PLoS ONE, 2012 The Antarctic icefish Chaenocephalus aceratus lacks the globins common to most vertebrates, hemoglobin and myoglobin, but has retained neuroglobin in the brain. This conserved globin has been cloned, over-expressed and purified. To highlight similarities
Daniela Giordano +15 more
doaj +10 more sources
Insights into the Function of a Conserved Cys120 in Human Neuroglobin in Oxidative Stress Regulation of Breast Cancer Cells [PDF]
BiomoleculesHuman neuroglobin (Ngb) is a globin featuring a disulfide bond (Cys46–Cys55) and a redox-active cysteine residue (Cys120) and plays a dual role in cellular stress responses. In this study, we investigated how wild-type (WT) Ngb and its two mutants, C120S
Shu-Qin Gao +4 more
doaj +2 more sources
Protection by neuroglobin expression in brain pathologies [PDF]
Frontiers in Neurology, 2016 Astrocytes play an important role in physiological, metabolic and structural functions and, when impaired, they can be involved in various pathologies including Alzheimer, focal ischemic stroke and traumatic brain injury.
Eliana Baez +5 more
doaj +4 more sources
Neuroglobin, clues to function and mechanism
Molecular Aspects of Medicine, 2022 pre proof of review published on Molecular Aspects of Medicine Volume 84 article number ...
Cecile Exertier +2 more
exaly +5 more sources