Results 11 to 20 of about 3,990 (214)
Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation [PDF]
Biomolecules, 2023 Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes.
Anita S. Y. Chan +9 more
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Neuroglobin – recent developments
Biomolecular Concepts, 2014 Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative ...
Qiu Xin Yao, Chen Xiao Qian
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Neuroglobin-enriched secretome provides neuroprotection against hydrogen peroxide and mitochondrial toxin-induced cellular stress [PDF]
Cell StressAberrant response to physiological cell stress is part of the mechanisms underlying the development of diverse human diseases, including neuropathologies.
Giovanna Bastari +5 more
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An Antiapoptotic Neuroprotective Role for Neuroglobin [PDF]
International Journal of Molecular Sciences, 2010 Cell death associated with mitochondrial dysfunction is common in acute neurological disorders and in neurodegenerative diseases. Neuronal apoptosis is regulated by multiple proteins, including neuroglobin, a small heme protein of ancient origin. Neuroglobin is found in high concentration in some neurons, and its high expression has been shown to ...
Joanna Skommer, Nigel Birch
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Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups [PDF]
Current Issues in Molecular BiologyNeuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova +7 more
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Adaptations to hypoxia in the vertebrate retina. [PDF]
J PhysiolAbstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Jonz MG.
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Neuroglobin in rat brain neurons
Сибирский научный медицинский журнал, 2021 Neuroglobin is a metalloprotein expressed predominantly in a nervous system and involved in the functioning of cells in normal and pathological conditions. Despite numerous studies, information on its regional distribution is ambiguous.
E. V. Uzlova, S. M. Zimatkin
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Neuroprotective effect of neuroglobin in hypoxia/ischemia
Сибирский научный медицинский журнал, 2021 Neuroglobin is a representative of the globin group, an oxygen-binding protein which is predominantly expressed in the nervous system. Despite the large amount of conducted research, its role is still poorly understood.
E. V. Uzlova, S. M. Zimatkin
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Frontiers in Neurology, 2022 ObjectiveStroke is closely related to dementia, but there are few prospective studies on cognitive decline after stroke in patients with cerebral hemorrhage. Neuroglobin is an oxygen-binding protein mainly expressed in brain neurons.
Yu Gao, Bo Wang, Ye Miao, Yu Han
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Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds
Cells, 2021 Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain ...
George E. Barreto +2 more
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