Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
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Neuroglobin-enriched secretome provides neuroprotection against hydrogen peroxide and mitochondrial toxin-induced cellular stress [PDF]
Cell StressAberrant response to physiological cell stress is part of the mechanisms underlying the development of diverse human diseases, including neuropathologies.
Giovanna Bastari +5 more
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Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation [PDF]
Biomolecules, 2023 Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes.
Anita S. Y. Chan +9 more
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Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups [PDF]
Current Issues in Molecular BiologyNeuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova +7 more
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Neuroprotective roles and mechanisms of neuroglobin [PDF]
Neurological Research, 2009 The objectives of this work were to update and summarize recent experimental works on neuroglobin, mainly focus on its neuroprotective effects and the mechanisms.The literature was reviewed using PubMed database, and some of the recent findings from our laboratory were included.Neuroglobin is a recently discovered tissue globin with a high affinity for
Zhanyang Yu, Xiang Fan, Eng H Lo
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Neuroglobin and cytoglobin: two new members of globin family [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui +1 more
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An Antiapoptotic Neuroprotective Role for Neuroglobin [PDF]
International Journal of Molecular Sciences, 2010 Cell death associated with mitochondrial dysfunction is common in acute neurological disorders and in neurodegenerative diseases. Neuronal apoptosis is regulated by multiple proteins, including neuroglobin, a small heme protein of ancient origin. Neuroglobin is found in high concentration in some neurons, and its high expression has been shown to ...
Thomas Brittain +2 more
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Research on the Effects of Neuroglobin on Ferroptosis in the Nerve Cells
Chinese Medicine and Natural Products, 2023 Objectives The objective of this article was to explore the effects of neuroglobin (NGB) on ferroptosis in the nerve cells.
Wenjin Gao +4 more
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Targeting Retinal Neuroglial Vascular Unit Damage: Novel Therapeutic Strategies for Early-Stage Diabetic Retinopathy. [PDF]
J Diabetes ResDiabetic retinopathy (DR) is a prevalent chronic ocular complication of diabetes, which ranks as the leading cause of blindness in individuals aged 40 and above. Recent studies have demonstrated that neuroglial vascular unit (NGVU) injury leads to distinct fundus changes in DR, including exudates, cotton‐fluff spots, microangiomas, hemorrhages, and ...
Li X, Zhou H.
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Neuroglobin-promoted autophagy inhibits the proliferation, migration and invasion of human glioblastoma cells through the EGFR/PI3K/AKT/mTOR signaling pathway. [PDF]
J Transl MedNeuroglobin (Ngb) is a novel oxygen-binding or sensor protein that is present primarily in neurons and the brain. It plays a critical role in sensing oxygen and hypoxia signals and in transducing intracellular signaling pathways.
Li L +5 more
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