Results 21 to 30 of about 3,990 (214)
Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size. [PDF]
PLoS ONE, 2013 BACKGROUND: Stroke is a major cause of death and severe disability, but effective treatments are limited. Neuroglobin, a neuronal heme-globin, has been advocated as a novel pharmacological target in combating stroke and neurodegenerative disorders based ...
Zindy Raida +3 more
doaj +1 more source
Neuroglobin Ligand Binding Kinetics [PDF]
IUBMB Life, 2004 AbstractNeuroglobin, cytoglobin, and hemoglobins from Drosophila melanogaster and Arabidopsis thaliana were studied for their ligand binding properties versus temperature. These globins have a common feature of being hexacoordinated (via the distal histidine) under deoxy conditions, displaying an enhanced amplitude for the alpha absorption band at 560 ...
Kiger, Laurent +8 more
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Neuroglobin, estrogens, and neuroprotection [PDF]
IUBMB Life, 2011 AbstractGlobins have been found in glial cells and neurons of invertebrates and vertebrates. The first nerve globin has been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. In some invertebrates, the nerve globin reaches a millimolar concentration which is likely sufficient to sustain the aerobic metabolism and thus ...
De Marinis, Elisabetta +2 more
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Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke
Pharmaceutics, 2020 Therapies against stroke can restore the blood supply but cannot prevent the ischemic damage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an important role in the neuro-regeneration process after stroke; however, the ...
Santos Blanco +7 more
doaj +1 more source
Neuroglobin: an endogenous neuroprotectant [PDF]
Current Opinion in Pharmacology, 2008 Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain
David A, Greenberg +2 more
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Neurobiology of Disease, 2021 Mitochondrial diseases are among the most prevalent groups of inherited neurological disorders, affecting up to 1 in 5000 adults. Despite the progress achieved on the identification of gene mutations causing mitochondrial pathologies, they cannot be ...
Hélène Cwerman-Thibault +9 more
doaj +1 more source
Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin. [PDF]
PLoS ONE, 2012 The Antarctic icefish Chaenocephalus aceratus lacks the globins common to most vertebrates, hemoglobin and myoglobin, but has retained neuroglobin in the brain. This conserved globin has been cloned, over-expressed and purified. To highlight similarities
Daniela Giordano +15 more
doaj +1 more source
Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection [PDF]
Oxidative Medicine and Cellular Longevity, 2013 Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders. However, the underlying mechanisms of Ngb’s neuroprotection remain largely undefined. Mitochondria play critical roles in multiple physiological pathways including cell respiration, energy production,
Zhanyang Yu +2 more
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Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
Cells, 2021 Retinal neurodegeneration affects an increasing number of people worldwide causing vision impairments and blindness, reducing quality of life, and generating a great economic challenge.
Virginia Solar Fernandez +2 more
doaj +1 more source
Pharmacological Induction of Neuroglobin Expression [PDF]
Pharmacology, 2011 Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes. To identify small molecules capable of inducing Ngb protein expression, which might have therapeutic benefit, we examined Ngb expression by Western blot in cultured HN33 (mouse hippocampal neuron !
Kunlin, Jin +4 more
openaire +2 more sources