Results 41 to 50 of about 3,008 (200)

Nitric Oxide Production and Regulation in the Teleost Cardiovascular System

Antioxidants, 2022
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular ...
Daniela Giordano, Cinzia Verde, Paola Corti   +2 more
doaj   +1 more source

Genetic determinants of neuroglobin transcription [PDF]

neurogenetics, 2013
Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
R, Wang, E, Halper-Stromberg, M, Szymanski-Pierce, S S, Bassett, D, Avramopoulos   +4 more
openaire   +2 more sources

Pharmacological Induction of Neuroglobin Expression [PDF]

Pharmacology, 2011
Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes. To identify small molecules capable of inducing Ngb protein expression, which might have therapeutic benefit, we examined Ngb expression by Western blot in cultured HN33 (mouse hippocampal neuron !
Kunlin, Jin, Xiao Ou, Mao, Lin, Xie, Varghese, John, David A, Greenberg   +4 more
openaire   +2 more sources

Hyperthermal stability of neuroglobin and cytoglobin [PDF]

The FEBS Journal, 2005
Neuroglobin (Ngb) and cytoglobin (Cygb), recent additions to the globin family, display a hexa‐coordinated (bis‐histidyl) heme in the absence of external ligands. Although these proteins have the classical globin fold they reveal a very high thermal stability with a melting temperature (Tm) of 100 °C for Ngb and 95 °C for Cygb.
Hamdane, Djemel, Kiger, Laurent, Dewilde, Sylvia, Uzan, Julien, Burmester, Thorsten, Hankeln, Thomas, Moens, Luc, Marden, Michael C.   +7 more
openaire   +3 more sources

Neuroglobin – recent developments

Biomolecular Concepts, 2014
Abstract Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated.
Qiu Xin Yao, Chen Xiao Qian
openaire   +3 more sources

THE ROLE OF NEUROGLOBIN IN CEREBRAL ISCHEMIA / HYPOXIA AND OTHER NEUROPATHOLOGY

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
The aim of the study was to summarize literature data on the localization, functions and role of neuroglobin in ischemia / hypoxia of the brain and neuropathology of different genesis.
Zimatkin S. M., Bon L. I., Maksimovich N. Ye.   +2 more
doaj   +1 more source

Phylogeny of Echinoderm Hemoglobins. [PDF]

PLoS ONE, 2015
Recent genomic information has revealed that neuroglobin and cytoglobin are the two principal lineages of vertebrate hemoglobins, with the latter encompassing the familiar myoglobin and α-globin/β-globin tetramer hemoglobin, and several minor groups.
Ana B Christensen, Joseph L Herman, Maurice R Elphick, Kord M Kober, Daniel Janies, Gregorio Linchangco, Dean C Semmens, Xavier Bailly, Serge N Vinogradov, David Hoogewijs   +9 more
doaj   +1 more source

Korean Red Ginseng-induced astrocytic HIF-1α: A key regulator of neuroglobin derived from neural stem cell differentiation in physiologic retina and brain. [PDF]

J Ginseng Res
Background Neuroglobin (Ngb) and growth-associated protein (GAP) 43 in neurons are associated with axonal regeneration. Korean Red Ginseng Extract (KRGE) enhances glial fibrillary acidic protein (GFAP)-positive astrocytes and hypoxia-inducible factor-1α (
Moon S, Park J, Kim S, Kim M, Jeon HS, Kim H, Kim YM, Kim JY, Choi YK.   +8 more
europepmc   +2 more sources

Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer

Clinical Epigenetics, 2023
Background The incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of CRC research. Early and frequent DNA methylation tends to occur in cancer.
Qin Xiang, Dishu Zhou, Xinni Xiang, X. Le, Chaoqun Deng, Ran Sun, Chunhong Li, Huayang Pang, Jin He, Zeze Zheng, Jun Tang, Weiyan Peng, Xi Peng, Xiaoqian He, Fan Wu, Jingfu Qiu, Yongzhu Xu, T. Xiang   +17 more
semanticscholar   +1 more source

Neuroglobin as a biomarker in children with autism spectrum disorder. [PDF]

Minia Journal of Medical Research
Neuroglobin as a biomarker in children with autism spectrum disorder.Abstract:Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions diagnosed based on behavioral assessments that reveal deficits in social interactions ...
Samir Mounir, Ahmed Saedii, Aya Mohamed, Yossra Fadle   +3 more
doaj   +1 more source