Results 41 to 50 of about 2,655 (162)

Oxygenaging: A Physiological Framework for Geroscience

Aging Cell, Volume 25, Issue 9, September 2026.
Mechanisms of aging disrupt oxygen homeostasis through three converging processes: oxygen‐cascade impairment, microvascular dysfunction, and molecular maladaptation. “Oxygenaging” integrates these domains to explain how declining oxygen delivery and utilization drive mitochondrial instability and amplify the effect of the hallmarks of aging.
Stefano Donega, Kenneth W. Fishbein, Paolo Dominelli, Allison B. Herman, Rafael de Cabo, Myriam Gorospe, Luigi Ferrucci   +6 more
wiley   +1 more source

Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells

Molecules, 2021
Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several processes, displaying a pivotal redox-dependent protective role in neuronal and extra-neuronal cells. NGB remarkably exerts its function upon upregulation by NGB inducers,
Michele Costanzo, Marco Fiocchetti, Paolo Ascenzi, Maria Marino, Marianna Caterino, Margherita Ruoppolo   +5 more
doaj   +1 more source

The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressive neurodegeneration.
Zhengxiang Lv, Xiaodong Liu, Qin Huang, Haijun Liu, Zucai Xu, Ping Xu   +5 more
wiley   +1 more source

Neuroglobin-prion protein interaction: what's the function?

, 2011
Neuroglobin and cellular prion protein (PrPC) are expressed in the nervous system and co-localized in the retinal ganglion cell layer. Both proteins do not have an unambiguously assigned function, and it was recently reported that PrPC aggregates rapidly
Arcovito A., Giovanni Luca Scaglione, Brunori M., Vitale R. M., Beatrice Vallone, Maria R. Vitale, Ettore Benedetti, Alessandro Arcovito, VALLONE, Beatrice, Amodeo P., ROSSI, FILOMENA, Maurizio Brunori, Filomena Rossi, Rosa Maria Vitale, Scaglione G. L., Vallone B., Pasquale Palladino, Pietro Amodeo, BRUNORI, Maurizio, Palladino P., Benedetti E., Palladino, P.   +21 more
core   +1 more source

Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer

Cells, 2021
The expression of the α-subtype of Estrogen Receptor (ERα) characterizes most breast cancers (more than 75%), for which endocrine therapy is the mainstay for their treatment.
Virginia Solar Fernandez, Marco Fiocchetti, Manuela Cipolletti, Marco Segatto, Paolo Cercola, Annalisa Massari, Sabrina Ghinassi, Francesco Cavaliere, Maria Marino   +8 more
doaj   +1 more source

Vesicular Rps6 Released by Astrocytes in an Experimental Model of AD Regulates Local Translation and Enhances Synaptic Integrity in Neurones

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover. Defects in protein homeostasis frequently lead to neuronal dysfunction and neurological disorders.
María Gamarra, Aida de la Cruz‐Gambra, Maite Blanco‐Urrejola, Esperanza González, Mikel Azkargorta, Felix Elortza, Juan Manuel Falcón‐Pérez, Jimena Baleriola   +7 more
wiley   +1 more source

Structural and (Pseudo-)Enzymatic Properties of Neuroglobin: Its Possible Role in Neuroprotection

Cells, 2021
Neuroglobin (Ngb), the third member of the globin family, was discovered in human and murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and hemoglobin (Hb) α and β subunits, but it hosts a bis-histidyl six-coordinated
Giovanna De Simone, Diego Sbardella, Francesco Oddone, Alessandra Pesce, Massimo Coletta, Paolo Ascenzi   +5 more
doaj   +1 more source

Neuroglobin and friends

, 2017
In the year 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Neuroglobin overexpression significantly protects both heart and brain from hypoxic/ischemic and oxidative stress-related insults,
Fabio Polticelli, Cipolletti, Manuela, Valentina Brandi, Manuela Cipolletti, Ascenzi, Paolo, Paolo Ascenzi, Brandi, Valentina, Fiocchetti, Marco, Marco Fiocchetti, Polticelli, Fabio   +9 more
core   +1 more source

The Effect of Repeated Restraint Stress on Neuroglobin-Oligodendrocytes Functions in the CA3 Hippocampal Area and Their Involvements in the Signaling Pathways of the Stress-Induced Anxiety

Applied Sciences, 2022
The present work shows the biochemical and structural fundamentals for the stress induced anxiety and stress adjustment response of the CA3 hippocampus area.
Vlad-Alexandru Toma, Bogdan Dume, Rareș Trâncă, Bogdan Sevastre, Lucian Barbu, Gabriela Adriana Filip, Ioana Roman, Alexandra-Cristina Sevastre-Berghian   +7 more
doaj   +1 more source

Seizure Activity and Hypoxia Differentially Regulate Endogenous Neurotrophic Activin A and Neuroglobin Expression in the Immature Mouse Brain

International Journal of Developmental Neuroscience, Volume 85, Issue 5, August 2025.
We investigated the regulatory effects of seizure‐induced excitotoxicity and acute hypoxia on the cytoprotective activin A and Ngb systems in the developing mouse brain. Our results demonstrate the differential regulation of Ngb and activin A as a function of time and type of injury and suggest their potential role as biomarkers of excitotoxic and ...
Clara Becker, Susan Jung, Regina Trollmann   +2 more
wiley   +1 more source