Results 51 to 60 of about 3,008 (200)
Comparative genomics of neuroglobin reveals its early origins. [PDF]
PLoS ONE, 2012 Neuroglobin (Ngb) is a hexacoordinated globin expressed mainly in the central and peripheral nervous system of vertebrates. Although several hypotheses have been put forward regarding the role of neuroglobin, its definite function remains uncertain.
Jasmin Dröge +3 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 Breast cancer is the first leading tumor in women in terms of incidence worldwide. Seventy percent of cases are estrogen receptor (ER) α-positive. In these malignancies, 17β-estradiol (E2) via ERα increases the levels of neuroglobin (NGB), a compensatory
E. Montalesi +12 more
semanticscholar +1 more source
Molecules, 2021 Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several processes, displaying a pivotal redox-dependent protective role in neuronal and extra-neuronal cells. NGB remarkably exerts its function upon upregulation by NGB inducers,
Michele Costanzo +5 more
doaj +1 more source
Neuroglobin Protection in Retinal Ischemia [PDF]
Investigative Opthalmology & Visual Science, 2012 Neuroglobin (Ngb) is a vertebrate globin that is predominantly expressed in the retina and brain. To explore the role of Ngb in retinal neuroprotection during ischemia reperfusion (IR), the authors examined the effect of Ngb overexpression in the retina in vivo by using Ngb-transgenic (Ngb-Tg) mice.Retinal IR was induced in Ngb overexpressing Ngb-Tg ...
Anita S Y, Chan +4 more
openaire +2 more sources
Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer
Cells, 2021 The expression of the α-subtype of Estrogen Receptor (ERα) characterizes most breast cancers (more than 75%), for which endocrine therapy is the mainstay for their treatment.
Virginia Solar Fernandez +8 more
doaj +1 more source
A neuroglobin-overexpressing transgenic mouse [PDF]
Gene, 2007 Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan +6 more
openaire +2 more sources
Cells, 2019 Neuroglobin is a heme protein of which increased levels provide neuroprotection against amyloid proteinopathy and hemorrhagic damage. These cellular stressors involve the promotion of ferroptosis—an iron-dependent, lipid peroxide-accreting form of ...
Zoë P. Van Acker +7 more
doaj +1 more source
Structural and (Pseudo-)Enzymatic Properties of Neuroglobin: Its Possible Role in Neuroprotection
Cells, 2021 Neuroglobin (Ngb), the third member of the globin family, was discovered in human and murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and hemoglobin (Hb) α and β subunits, but it hosts a bis-histidyl six-coordinated
Giovanna De Simone +5 more
doaj +1 more source
Neuroglobin immunoreactivity in the human cochlea [PDF]
Brain Research, 2016 Neuroglobin (Ngb) is an oxygen-binding protein with a demonstrated role in endogenous neuroprotective mechanisms. It has been shown to function as a scavenger for reactive oxidizing species thereby assisting in cellular defense against oxidative stress. In the present study, we characterized the presence of Ngb in the human cochlea. Immunohistochemical
Vorasubin, Nopawan +5 more
openaire +4 more sources
Applied Sciences, 2022 The present work shows the biochemical and structural fundamentals for the stress induced anxiety and stress adjustment response of the CA3 hippocampus area.
Vlad-Alexandru Toma +7 more
doaj +1 more source