Results 71 to 80 of about 3,990 (214)
The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients [PDF]
, 2013 BACKGROUND: Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. METHODS: We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor ...
Guo-Jun Zhang +12 more
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Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling [PDF]
, 2014 Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN.
Bidon Chanal, Axel +12 more
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British Journal of Haematology, Volume 206, Issue 6, Page 1585-1592, June 2025.Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs +13 more
wiley +1 more source
Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice
Molecular Therapy: Methods & Clinical Development, 2017 Mitochondrial dysfunction is responsible for hereditary optic neuropathies. We wished to determine whether preserving mitochondrial bioenergetics could prevent optic neuropathy in a reliable model of glaucoma.
Hélène Cwerman-Thibault +12 more
doaj +1 more source
Brain and Behavior, 2020 Background The neuroglobin (Ngb) is well recognized as a potential biomarker for the hypoxic‐ischemic brain injury. However, connection between Ngb and delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is still unclear ...
Chenyu Ding +7 more
doaj +1 more source
Frontiers in Neuroscience, 2020 In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defend ...
Silvia de Vidania +11 more
doaj +1 more source
Strategies for synthesis of yardsticks and abaci for nanometre distance measurements by pulsed EPR [PDF]
, 2014 Silvia Valera is grateful for support by EPSRC and Bela E. Bode acknowledges support by EastCHEM.Pulsed electron paramagnetic resonance (EPR) techniques have been found to be an efficient tool for elucidation of structure in complex biological systems as
Bode, Bela Ernest, Valera, Silvia
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Brain and Behavior, Volume 15, Issue 4, April 2025.ABSTRACT Purpose Patients undergoing open‐heart surgery often face significant challenges in postoperative cognitive dysfunction (POCD). There has been growing interest in understanding how anesthesia medications, such as dexmedetomidine (DEX) and midazolam, impact cognitive function in these patients.
Masoomeh Tabari +3 more
wiley +1 more source
Effect of the distal histidine on the peroxidatic activity of monomeric cytoglobin [PDF]
, 2015 The reaction of hydrogen peroxide with ferric human cytoglobin and a number of distal histidine variants were studied. The peroxidase activity of the monomeric wildtype protein with an internal disulfide bond, likely to be the form of the protein in vivo,
A Gardner +39 more
core +2 more sources