Results 71 to 80 of about 2,655 (162)
Chimeric ZHHH neuroglobin acts as a cell membrane‐penetrating inducer of neurite outgrowth
FEBS Open Bio, 2017 Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has a cell membrane ...
Nozomu Takahashi +3 more
doaj +1 more source
Physiological Reports, Volume 12, Issue 17, September 2024.Abstract Diving marine mammals are a diverse group of semi‐ to completely aquatic species. Some species are targets of conservation and rehabilitation efforts; other populations are permanently housed under human care and may contribute to clinical and biomedical investigations.
Carolina R. Le‐Bert +2 more
wiley +1 more source
A role for human neuroglobin in apoptosis.
, 2010 Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action.
Thomas Brittain +9 more
core +1 more source
UPREGULATION OF NEUROGLOBIN PROMOTES TM3 LEYDIG CELL VIABILITY
Trakya University Journal of Natural Sciences, 2018 Neuroglobin (NGB) is a globin family member protein expressed in the nerve system and prevents oxidative stress and apoptosis induced death in neurons. The anti-oxidant role of NGB against oxidative stress and reactive oxygen species (ROS) brings up its ...
Aysegul Dogan
doaj +1 more source
Iron–histidine bonding in bishistidyl hemoproteins–A local vibrational mode study
Journal of Computational Chemistry, Volume 45, Issue 9, Page 574-588, April 5, 2024.Using our local mode analysis, the strength of FeN distal and proximal bonds was investigated for bishistidyl proteins from bacteria, animals, human, and plants via local mode force constants ka(FeN). We also investigated the stiffness of the axial NFeN bond angle via local mode force constants ka(NFeN).
Marek Freindorf +2 more
wiley +1 more source
Neuroglobin and Cytoglobin expression in the human brain
, 2013 Neuroglobin and Cytoglobin are new members of the heme-globin family. Both globins are primarily expressed in neurons of the brain and retina. Neuroglobin and Cytoglobin have been suggested as novel therapeutic targets in various neurodegenerative ...
Kelsen, Jesper +2 more
core +1 more source
Frontiers in Pharmacology, 2020 BackgroundExploring the effective therapy for neonatal hypoxic-ischemic brain injury is an important goal. This study was designed to investigate how dexmedetomidine (DEX) contribute to hypoxic brain injury.MethodsDeveloping Sprague-Dawley rat models of ...
Yan Gao +4 more
doaj +1 more source
Pulmonary Circulation, Volume 14, Issue 2, April 2024.Abstract Pulmonary hypertension in sickle cell disease (SCD) is a complex phenomenon resulting from multiple overlapping etiologies, including pulmonary vasoconstriction in the setting of chronic hemolytic anemia, diastolic dysfunction, and chronic thromboembolic disease.
Kadija Hersi +6 more
wiley +1 more source
A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cells.
, 2008 We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c
Thomas Brittain +5 more
core +1 more source
大鼠急性青光眼模型中neuroglobin在视网膜的表达上调作用
Zhongguo shiyan zhenduanxue, 2008 目的研究大鼠急性青光眼模型中neuroglobin（NGB）的表达变化。方法制备大鼠急性青光眼模型,采用RT-PCR技术动态观察不同缺血时间点NGB mRNA水平变化,并对数据进行分析。结果视网膜缺血1 min,neuroglobinmRNA表达迅速上升,5 min时neuroglobin mRNA表达保持在高水平,到10 min时达高峰,缺血20 min表达已下降,但仍高于正常水平;此后缺血30 min、60 min时neuroglobin mRNA均保持在较低水平,且低于正常水平 ...
李中秋, 杜园园, 王晶, 卢弘
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