Results 81 to 90 of about 2,655 (162)

Acute hypoxia modifies regulation of neuroglobin in the neonatal mouse brain [PDF]

, 2012
Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant.
Hümmler, Nicolas, Schneider, Christina, Walkinshaw, Gail, Bauer, Reinhard, Rascher, Wolfgang, Gassmann, Max, Trollmann, Regina, Giessl, Andreas   +7 more
core   +1 more source

Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1

, 2018
Neuroglobin is an endogenous neuroprotective protein, but the underlying neuroprotective mechanisms remain to be elucidated. Our previous yeast two-hybrid screening study identified that Dishevelled-1, a key hub protein of Wnt/β-Catenin signaling ...
Yingxin Tang, Shengwen Long, Jiabing Li, Fen Tang, Yu Xun, Ye Xiao, Manjun Yang, Ning Liu, Pan Shu, Zhen Li, Chenxi Wei, Shuanglin Xiang   +11 more
core   +1 more source

Effects of Exogenous Neuroglobin (Ngb) on retinal inflammatory chemokines and microglia in a rat model of transient hypoxia [PDF]

, 2019
Neuroglobin is an endogenous neuroprotective protein. We determined the safety of direct delivery of Neuroglobin in the rat retina and its effects on retinal inflammatory chemokines and microglial during transient hypoxia.
Lynn, MN, Chan, ASY, Lynn, M.N., Tun, S.B.B., Luu, CD, Chan, A.S.Y., Barathi, VA, Barathi, V.A., Tun, SBB, Luu, C.D.   +9 more
core   +1 more source

Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes

International Journal of General Medicine, 2022
Sawsan Abuhamdah,1,2 Tahia H Saleem,3 Bakheet EM Elsadek,4 Omyma Ashraf,5 Ali R Hamdan,6 Eslam El Sayed El-Khateeb,6 Saeda M Abd Elwahab,7 Mohammed H Hassan5 1College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates; 2Department of ...
Abuhamdah S, Saleem TH, Elsadek BE, Ashraf O, Hamdan AR, El-Khateeb EES, Abd Elwahab SM, Hassan MH   +7 more
doaj  

The human brain hexacoordinated neuroglobin three-dimensional structure

, 2004
Neuroglobin, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O2 supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage.
M. Bolognesi, Bolognesi, M., Dewilde, Sylvia, Nardini, M., M. Nardini, Ascenzi, P., L. Moens, Burmester, T., A. Pesce, Hankeln, T., S. Dewilde, T. Burmester, Pesce, A., T. Hankeln, Moens, Luc, P. Ascenzi   +15 more
core   +1 more source

Neuroglobin

Bakalářská práce je zaměřena na strukturu, vlastnosti a význam neuroglobinu. V úvodní části je stručně popsána struktura metaloproteinů a popis dvou základních zástupců (hemoglobin, myoglobin).
Petříková, Simona
core   +1 more source

Cognitive Deficits Are Attenuated in Neuroglobin Overexpressing Mice Exposed to a Model of Obstructive Sleep Apnea

Frontiers in Neurology, 2018
Background: Obstructive sleep apnea (OSA) is a highly prevalent disease manifesting as intermittent hypoxia during sleep (IH) and is increasingly recognized as being independently associated with neurobehavioral deficits.
Deepti Nair, Deepti Nair, Deepti Nair, Vijay Ramesh, David Gozal   +4 more
doaj   +1 more source

Glioblastoma, IDH-Wildtype, Developing in the Territory of a Prior Hemorrhagic Stroke: A Case Report

Indian Journal of Neurosurgery
Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis, marked by vascular endothelial growth factor -driven angiogenesis. Hemorrhagic stroke causes cerebral vessel rupture, hypoxia, and neuronal injury, and may trigger reactive ...
Kushal Shah, Renish Padshala, Varshesh Shah, Md Nazar Imam, Dharmikkumar Velani, Krushi Soladhra, Kalpesh Shah, Viral Sutariya, Kartik Vala   +8 more
doaj   +1 more source

The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats

Frontiers in Neuroscience, 2019
BackgroundMany studies have reported that sevoflurane can increase neuronal apoptosis and result in cognitive deficits in rodents. Although neurotoxicity may be associated with mitochondrial dysfunction and oxidative stress, the exact mechanism remains ...
Fan Yang, Yangyang Shan, Zhiyin Tang, Xiuying Wu, Congjie Bi, Yongfang Zhang, Yan Gao, Hongtao Liu   +7 more
doaj   +1 more source

Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups

Current Issues in Molecular Biology
Neuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova, Zhanna V. Bochkova, Olga M. Smirnova, Georgy V. Maksimov, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Nadezda A. Brazhe, Rita V. Chertkova   +7 more
doaj   +1 more source