Results 81 to 90 of about 3,990 (214)

Neuroglobin immunoreactivity in the human cochlea [PDF]

Brain Research, 2016
Neuroglobin (Ngb) is an oxygen-binding protein with a demonstrated role in endogenous neuroprotective mechanisms. It has been shown to function as a scavenger for reactive oxidizing species thereby assisting in cellular defense against oxidative stress. In the present study, we characterized the presence of Ngb in the human cochlea. Immunohistochemical
Vorasubin, Nopawan, Hosokawa, Seiji, Hosokawa, Kumiko, Ishiyama, Gail, Ishiyama, Akira, Lopez, Ivan A   +5 more
openaire   +4 more sources

Iron‐Histidine Coordination in Cytochrome b5: A Local Vibrational Mode Study

ChemPhysChem, Volume 26, Issue 7, April 1, 2025.
Distal/proximal FeN bond strength and axial NFeN angle stiffness in a series of cytochrome b5s, isolated from different species such as bacteria, animals, and human were investigated with our local vibrational mode analysis combined with QM/MM calculations.
Marek Freindorf, Kevin Fleming, Elfi Kraka   +2 more
wiley   +1 more source

Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

IUCrJ, 2019
A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in gas ...
Chiara Ardiccioni, Alessandro Arcovito, Stefano Della Longa, Peter van der Linden, Dominique Bourgeois, Martin Weik, Linda Celeste Montemiglio, Carmelinda Savino, Giovanna Avella, Cécile Exertier, Philippe Carpentier, Thierry Prangé, Maurizio Brunori, Nathalie Colloc'h, Beatrice Vallone   +14 more
doaj   +1 more source

Molecular simulations of globins: Exploring the relationship between structure, dynamics and function [PDF]

, 2011
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392The discovery in the last two decades of novel members of the globin superfamily has challenged the conventional view about the structure and function of globins.
Arroyo, Pau, Bidon-Chanal Badia, Axel, Bikiel, Damian, Boechi, Leonardo, Capece, Luciana, Estrín, Darío, Forti, Flavio, Luque Garriga, F. Xavier, Martí, Marcelo A., Nadra, Alejandro, Novo de Oliveira, Ana Luísa   +10 more
core  

Arginine metabolism is a biomarker of red blood cell and human aging

Aging Cell, Volume 24, Issue 2, February 2025.
Reisz et al. examined age‐related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The study identifies alterations in arginine metabolism associated with chronological age, linking them to erythrocyte function, vesiculation, and post ...
Julie A. Reisz, Eric J. Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R. Keele, Monika Dzieciatkowska, Steven L. Spitalnik, Eldad A. Hod, Steven Kleinman, Nareg H. Roubinian, Mark T. Gladwin, Kirk C. Hansen, Philip J. Norris, Michael P. Busch, James C. Zimring, Gary A. Churchill, Grier P. Page, Angelo D'Alessandro   +18 more
wiley   +1 more source

Circadian Behaviour in Neuroglobin Deficient Mice

PLoS ONE, 2012
Neuroglobin (Ngb), a neuron-specific oxygen-binding globin with an unknown function, has been proposed to play a key role in neuronal survival. We have previously shown Ngb to be highly expressed in the rat suprachiasmatic nucleus (SCN). The present study addresses the effect of Ngb deficiency on circadian behavior.
Hundahl, Christian A, Fahrenkrug, Jan, Hay-Schmidt, Anders, Georg, Birgitte, Faltoft, Birgitte, Hannibal, Jens   +5 more
openaire   +5 more sources

Effects of patent foramen ovale in migraine: a metabolomics‐based study

The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong, Xin Li, Lu Zhang, Ge Liang, Wen Zheng, Luolan Gui, Shuming Ji, Yusha Tang, Hua Li, Wanling Li, Ruiqi Yang, Yajiao Li, Anjiao Peng, Yucheng Chen, Meng Gong, Lei Chen   +15 more
wiley   +1 more source

Glucagon-like peptide-1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria [PDF]

, 2016
BACKGROUND: Cerebral malaria from Plasmodium falciparum infection is major cause of death in the tropics. The pathogenesis of the disease is complex and the contribution of reactive oxygen and nitrogen species (ROS/RNS) in the brain is incompletely ...
Brian DellaValle, Casper Hempel, Flemming Fryd Johansen, Jørgen Anders Lindholm Kurtzhals, Trine Staalsoe   +4 more
core   +1 more source

Neuroprotective roles and mechanisms of neuroglobin [PDF]

Neurological Research, 2009
The objectives of this work were to update and summarize recent experimental works on neuroglobin, mainly focus on its neuroprotective effects and the mechanisms.The literature was reviewed using PubMed database, and some of the recent findings from our laboratory were included.Neuroglobin is a recently discovered tissue globin with a high affinity for
Zhanyang, Yu, Xiang, Fan, Eng H, Lo, Xiaoying, Wang   +3 more
openaire   +2 more sources

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source