Nitrite in Organ Protection [PDF]
, 2014 In the last decade, the nitrate-nitrite-nitric oxide (NO) pathway has emerged to therapeutical importance. Modulation of endogenous nitrate and nitrite levels with the subsequent S-nitros(yl)ation of the downstream signalling cascade open the way for ...
Aamand +133 more
core +1 more source
Human neuroglobin protein in cerebrospinal fluid.
Proteome science, 2005 BACKGROUND: Neuroglobin is a hexacoordinated member of the globin family of proteins. It is predominantly localized to various brain regions and retina where it may play a role in protection against ischemia and nitric oxide-induced neural injury.
Casado, Begona +4 more
openaire +4 more sources
Iron–histidine bonding in bishistidyl hemoproteins–A local vibrational mode study
Journal of Computational Chemistry, Volume 45, Issue 9, Page 574-588, April 5, 2024.Using our local mode analysis, the strength of FeN distal and proximal bonds was investigated for bishistidyl proteins from bacteria, animals, human, and plants via local mode force constants ka(FeN). We also investigated the stiffness of the axial NFeN bond angle via local mode force constants ka(NFeN).
Marek Freindorf +2 more
wiley +1 more source
Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools [PDF]
, 2010 We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats.
Arne Møller +8 more
core +2 more sources
Pulmonary Circulation, Volume 14, Issue 2, April 2024.Abstract Pulmonary hypertension in sickle cell disease (SCD) is a complex phenomenon resulting from multiple overlapping etiologies, including pulmonary vasoconstriction in the setting of chronic hemolytic anemia, diastolic dysfunction, and chronic thromboembolic disease.
Kadija Hersi +6 more
wiley +1 more source
Plant hemoglobins can be maintained in functional form by reduced flavins in the nuclei and confer differential tolerance to nitro-oxidative stress [PDF]
, 2013 39 Pags., 1 Tabl., 5 Figs., with Supplementary Supporting Information (1 Suppl. Tabl., 5 Suppl. Figs.). The definitive version is available at: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-313XThe heme of bacteria, plant and animal ...
Becana Ausejo, Manuel +7 more
core +2 more sources
Transfusion, Volume 64, Issue 4, Page 615-626, April 2024.Abstract Background Donor genetic variation is associated with red blood cell (RBC) storage integrity and post‐transfusion recovery. Our previous large‐scale genome‐wide association study demonstrated that the African G6PD deficient A‐ variant (rs1050828, Val68Met) is associated with higher oxidative hemolysis after cold storage.
Ling Wang +14 more
wiley +1 more source
大鼠急性青光眼模型中neuroglobin在视网膜的表达上调作用
Zhongguo shiyan zhenduanxue, 2008 目的研究大鼠急性青光眼模型中neuroglobin（NGB）的表达变化。方法制备大鼠急性青光眼模型,采用RT-PCR技术动态观察不同缺血时间点NGB mRNA水平变化,并对数据进行分析。结果视网膜缺血1 min,neuroglobinmRNA表达迅速上升,5 min时neuroglobin mRNA表达保持在高水平,到10 min时达高峰,缺血20 min表达已下降,但仍高于正常水平;此后缺血30 min、60 min时neuroglobin mRNA均保持在较低水平,且低于正常水平 ...
李中秋, 杜园园, 王晶, 卢弘
doaj
Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer [PDF]
, 2017 Recently, the ectopic expression of myoglobin (MB) was reported in human epithelial cancer cell lines and breast tumor tissues, where MB expression increased with hypoxia.
Bicker, Anne +5 more
core
Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death. [PDF]
, 2014 Phthalates, phthalic acid esters, are widely used as plasticizers to produce polymeric materials in industrial production of plastics and daily consumable products.
Canzoniero LM +8 more
core +1 more source