Results 91 to 100 of about 3,990 (214)

The role of microglia in neurocognitive deficits induced by general anaesthetic agents during neurodevelopment

Clinical and Translational Discovery, Volume 4, Issue 6, December 2024.
Under GAAs, microglia are activated towards M1 (pro‐inflammatory) phenotype through direct and indirect ways. Microglia‐mediated neuroinflammation induce neuronal death, synaptic loss and dysmyelination in developing brain, which might be a key mechanism of neurocognitive deficits during neurodevelopment.
Xinyue Liang, Fang Fang, Xiaoqing Wang, Ming Jiang, Jing Cang   +4 more
wiley   +1 more source

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans [PDF]

, 2015
Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined.
Alexander, Alexander, Angelo, Badejo, Bailey, Baliga, Basu, Chen, Cosby, D'Souza, Dejam, DiFabio, Doyle, Furchgott, Ghosh, Gladwin, Golwala, Greenstein, Huellner, Huffman, Irvine, Johansson, Keith, Kollau, Koppaka, Larsen, Li, Lundberg, Mackenzie, Madhani, Maher, Maher, Marti, Ormerod, Paneni, Pawson, Perlman, Pinder, Tiso, Totzeck   +39 more
core   +2 more sources

Comparative protein interactomics of neuroglobin and myoglobin [PDF]

Journal of Neurochemistry, 2012
AbstractNeuroglobin is a hypoxia‐inducible O2‐binding protein with neuroprotective effects in cell and animal models of stroke and Alzheimer’s disease. The mechanism underlying neuroglobin’s cytoprotective action is unknown, although several possibilities have been proposed, including anti‐oxidative and anti‐apoptotic effects.
Bryan A, Haines, Darcy A, Davis, Artem, Zykovich, Botao, Peng, Rammohan, Rao, Sean D, Mooney, Kunlin, Jin, David A, Greenberg   +7 more
openaire   +2 more sources

Molecularly Imprinted Nanoparticle‐Based Polymer (Acrylamide‐N‐Vinyl imidazole)/Nafion Film Modified Screen‐Printed Electrode System for Rapid Determination of Hemoglobin

Electroanalysis, Volume 36, Issue 12, December 2024.
Abstract In medical diagnostics, variations in hemoglobin levels can reveal a variety of prevalent health conditions. Abnormal hemoglobin is known to be connected with diseases like anemia, diabetes, hematemesis, hematuria, and hemoglobinuria. Consequently, there is a significant demand for advanced detection technologies and precise methodologies to ...
Hilal Özçelik, Esra Yaşar, Timuçin Güner, Emre Dokuzparmak, Koray Şarkaya, Sinan Akgöl   +5 more
wiley   +1 more source

Neuroglobin: Endogenous Neuroprotectant or Maintenance of Homeostasis? [PDF]

Stroke, 2008
To the Editor: We would like to comment on the latest experimental stroke study in a neuroglobin (Ngb) knock-in mouse by Wang et al1 The intriguing idea that Ngb could act as a reservoir of oxygen, facilitate oxygen transportation or act as a scavenger of reactive oxygen species in the brain has been the main research hypotheses since its discovery.2 ...
Kelsen, J., Hundahl, C.A., Hay-Schmidt, A.   +2 more
openaire   +2 more sources

Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases

Brain and Behavior, Volume 14, Issue 11, November 2024.
Dexmedetomidine has demonstrated potent neuroprotective effects in a variety of brain disorders, and this may be achieved by inhibiting inflammatory responses, attenuating oxidative stress, reducing apoptosis and autophagy, and improving the immune microenvironment.
Zhenxing Tao, Pengpeng Li, Xudong Zhao
wiley   +1 more source

Chimeric ZHHH neuroglobin acts as a cell membrane‐penetrating inducer of neurite outgrowth

FEBS Open Bio, 2017
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has a cell membrane ...
Nozomu Takahashi, Wataru Onozuka, Seiji Watanabe, Keisuke Wakasugi   +3 more
doaj   +1 more source

UPREGULATION OF NEUROGLOBIN PROMOTES TM3 LEYDIG CELL VIABILITY

Trakya University Journal of Natural Sciences, 2018
Neuroglobin (NGB) is a globin family member protein expressed in the nerve system and prevents oxidative stress and apoptosis induced death in neurons. The anti-oxidant role of NGB against oxidative stress and reactive oxygen species (ROS) brings up its ...
Aysegul Dogan
doaj   +1 more source

Cardiopulmonary adaptations of a diving marine mammal, the bottlenose dolphin: Physiology during anesthesia

Physiological Reports, Volume 12, Issue 17, September 2024.
Abstract Diving marine mammals are a diverse group of semi‐ to completely aquatic species. Some species are targets of conservation and rehabilitation efforts; other populations are permanently housed under human care and may contribute to clinical and biomedical investigations.
Carolina R. Le‐Bert, Gordon S. Mitchell, Leah R. Reznikov   +2 more
wiley   +1 more source

Dexmedetomidine Mediates Neuroglobin Up-Regulation and Alleviates the Hypoxia/Reoxygenation Injury by Inhibiting Neuronal Apoptosis in Developing Rats

Frontiers in Pharmacology, 2020
BackgroundExploring the effective therapy for neonatal hypoxic-ischemic brain injury is an important goal. This study was designed to investigate how dexmedetomidine (DEX) contribute to hypoxic brain injury.MethodsDeveloping Sprague-Dawley rat models of ...
Yan Gao, Yongfang Zhang, Yunxia Dong, Xiuying Wu, Hongtao Liu   +4 more
doaj   +1 more source