Results 91 to 100 of about 3,008 (200)

Neuroglobins: a look into the future

The European Research Journal, 2019
No abstract available. 
Ayush Dubey, Shubham Dubey
openaire   +3 more sources

Neuroglobin: A Respiratory Protein of the Nervous System [PDF]

Physiology, 2004
Nerve tissues exhibit some of the highest oxygen consumption rates found in the body. Neuroglobin, a heme protein distantly related to hemoglobin, is thought to enhance the supply of oxygen to the neurons, the eye, and some endocrine tissues. Neuroglobin may promote neuronal survival under hypoxic conditions as they occur, for example, in stroke.
Thorsten, Burmester, Thomas, Hankeln
openaire   +2 more sources

Iron–histidine bonding in bishistidyl hemoproteins–A local vibrational mode study

Journal of Computational Chemistry, Volume 45, Issue 9, Page 574-588, April 5, 2024.
Using our local mode analysis, the strength of FeN distal and proximal bonds was investigated for bishistidyl proteins from bacteria, animals, human, and plants via local mode force constants ka(FeN). We also investigated the stiffness of the axial NFeN bond angle via local mode force constants ka(NFeN).
Marek Freindorf, Juliana J. Antonio, Elfi Kraka   +2 more
wiley   +1 more source

Chimeric ZHHH neuroglobin acts as a cell membrane‐penetrating inducer of neurite outgrowth

FEBS Open Bio, 2017
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has a cell membrane ...
Nozomu Takahashi, Wataru Onozuka, Seiji Watanabe, Keisuke Wakasugi   +3 more
doaj   +1 more source

Diagnosis and management of chronic thromboembolic pulmonary hypertension (CTEPH) in sickle cell disease: A review

Pulmonary Circulation, Volume 14, Issue 2, April 2024.
Abstract Pulmonary hypertension in sickle cell disease (SCD) is a complex phenomenon resulting from multiple overlapping etiologies, including pulmonary vasoconstriction in the setting of chronic hemolytic anemia, diastolic dysfunction, and chronic thromboembolic disease.
Kadija Hersi, Gautam V. Ramani, Jennie Y. Law, Ahmed S. Sadek, Anjali Vaidya, Mark T. Gladwin, Steven J. Cassady   +6 more
wiley   +1 more source

NEUROGLOBIN IN CINGULATE CORTEX NEURONS OF THE RAT BRAIN IN CHOLESTASIS

Hepatology and Gastroenterology
Вackground. The study of neuroglobin will help to understand the mechanisms of neuroprotection and energy metabolism in neurons of different cingulate cortex layers in cholestasis. Objective. To evaluate the immunoreactivity of neuroglobulin in cingulate
T. V. Klimut, A. V. Zaerko, S. V. Emelyanchik, S. M. Zimatkin   +3 more
semanticscholar   +1 more source

Functional effects of an African glucose‐6‐phosphate dehydrogenase (G6PD) polymorphism (Val68Met) on red blood cell hemolytic propensity and post‐transfusion recovery

Transfusion, Volume 64, Issue 4, Page 615-626, April 2024.
Abstract Background Donor genetic variation is associated with red blood cell (RBC) storage integrity and post‐transfusion recovery. Our previous large‐scale genome‐wide association study demonstrated that the African G6PD deficient A‐ variant (rs1050828, Val68Met) is associated with higher oxidative hemolysis after cold storage.
Ling Wang, Elizabeth R. Rochon, Sebastien Gingras, Benjamin E. Zuchelkowski, Derek J. Sinchar, Elimira Alipour, Julie A. Reisz, Minying Yang, Grier P. Page, Tamir Kanias, Darrell J. Triulzi, Janet S. Lee, Daniel B. Kim‐Shapiro, Angelo D'Alessandro, Mark T. Gladwin   +14 more
wiley   +1 more source

Carbon monoxide affects early cardiac development in an avian model

Birth Defects Research, Volume 116, Issue 3, March 2024.
Abstract Introduction Carbon monoxide (CO) is a toxic gas that can be lethal in large doses and may also cause physiological damage in lower doses. Epidemiological studies suggest that CO in lower doses over time may impact on embryo development, in particular cardiac development, however other studies have not observed this association.
Filipa Rombo Matias, Ian Groves, Joshua Durrans, Mari Herigstad   +3 more
wiley   +1 more source

Prodromal Alzheimer’s Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer’s Pathology

Frontiers in Neuroscience, 2020
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defend ...
Silvia de Vidania, Irene Palomares-Perez, Ana Frank-García, Takashi Saito, Takaomi C. Saido, Jonathan Draffin, María Szaruga, Lucía Chávez-Gutierrez, Miguel Calero, Miguel Medina, Francesc X. Guix, Carlos G. Dotti   +11 more
doaj   +1 more source

Gene therapy for mitochondrial disorders

Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 145-175, January 2024.
Abstract In this review, we detail the current state of application of gene therapy to primary mitochondrial disorders (PMDs). Recombinant adeno‐associated virus‐based (rAAV) gene replacement approaches for nuclear gene disorders have been undertaken successfully in more than ten preclinical mouse models of PMDs which has been made possible by the ...
Nandaki Keshavan, Michal Minczuk, Carlo Viscomi, Shamima Rahman   +3 more
wiley   +1 more source