Results 111 to 120 of about 3,990 (214)
Carbon monoxide affects early cardiac development in an avian model
Birth Defects Research, Volume 116, Issue 3, March 2024.Abstract Introduction Carbon monoxide (CO) is a toxic gas that can be lethal in large doses and may also cause physiological damage in lower doses. Epidemiological studies suggest that CO in lower doses over time may impact on embryo development, in particular cardiac development, however other studies have not observed this association.
Filipa Rombo Matias +3 more
wiley +1 more source
Gene therapy for mitochondrial disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 145-175, January 2024.Abstract In this review, we detail the current state of application of gene therapy to primary mitochondrial disorders (PMDs). Recombinant adeno‐associated virus‐based (rAAV) gene replacement approaches for nuclear gene disorders have been undertaken successfully in more than ten preclinical mouse models of PMDs which has been made possible by the ...
Nandaki Keshavan +3 more
wiley +1 more source
International Journal of General Medicine, 2022 Sawsan Abuhamdah,1,2 Tahia H Saleem,3 Bakheet EM Elsadek,4 Omyma Ashraf,5 Ali R Hamdan,6 Eslam El Sayed El-Khateeb,6 Saeda M Abd Elwahab,7 Mohammed H Hassan5 1College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates; 2Department of ...
Abuhamdah S +7 more
doaj
Ultrafast 2D-IR spectroscopy of haemoproteins [PDF]
, 2015 Applications of ultrafast two-dimensional infrared (2D-IR) spectroscopy to study the structural dynamics of haem-containing proteins are reviewed. The 2D-IR experiments discussed exploit diatomic ligands bound to the haem as reporters on the dynamic ...
Hunt, N.T., Simpson, N.
core +1 more source
Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons [PDF]
, 2013 Hemoglobin is the oxygen carrier in blood erythrocytes. Oxygen coordination is mediated by α2β2 tetrameric structure via binding of the ligand to the heme iron atom. This structure is essential for hemoglobin function in the blood. In the last few years,
Russo, Roberta +5 more
core +1 more source
Influence of temperature on the topological features of inner cavities in cytoglobin [PDF]
, 2015 Cytoglobin (Cygb) is a novel member of the globin family in man, but there is no clear evidence about its biological function. Cygb exhibits a highly complex ligand rebinding kinetics, which agrees with the structural plasticity of the inner cavities ...
Bidon-Chanal, Axel +2 more
core
Constructing a man-made c-type cytochrome maquette in vivo:electron transfer, oxygen transport and conversion to a photoactive light harvesting maquette [PDF]
, 2014 The successful use of man-made proteins to advance synthetic biology requires both the fabrication of functional artificial proteins in a living environment, and the ability of these proteins to interact productively with other proteins and substrates in
Anderson, J. L. Ross +10 more
core +2 more sources
Frontiers in Neurology, 2018 Background: Obstructive sleep apnea (OSA) is a highly prevalent disease manifesting as intermittent hypoxia during sleep (IH) and is increasingly recognized as being independently associated with neurobehavioral deficits.
Deepti Nair +4 more
doaj +1 more source
Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion [PDF]
, 2013 PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion.
Bertoletto, Paulo Roberto +6 more
core +2 more sources
EPR characterisation of the ferrous nitrosyl complex formed within the oxygenase domain of NO synthase. [PDF]
, 2013 International audienceNitric oxide is produced in mammals by a class of enzymes called NO synthases (NOSs). It plays a central role in cellular signalling but also has deleterious effects, as it leads to the production of reactive oxygen and nitrogen ...
Boussac, Alain +3 more
core +4 more sources