Results 61 to 70 of about 2,655 (162)
Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments
IUCrJ, 2019 A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in gas ...
Chiara Ardiccioni +14 more
doaj +1 more source
Arginine metabolism is a biomarker of red blood cell and human aging
Aging Cell, Volume 24, Issue 2, February 2025.Reisz et al. examined age‐related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The study identifies alterations in arginine metabolism associated with chronological age, linking them to erythrocyte function, vesiculation, and post ...
Julie A. Reisz +18 more
wiley +1 more source
Effects of patent foramen ovale in migraine: a metabolomics‐based study
The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong +15 more
wiley +1 more source
Journal of Diabetes Research, Volume 2025, Issue 1, 2025.Diabetic retinopathy (DR) is a prevalent chronic ocular complication of diabetes, which ranks as the leading cause of blindness in individuals aged 40 and above. Recent studies have demonstrated that neuroglial vascular unit (NGVU) injury leads to distinct fundus changes in DR, including exudates, cotton‐fluff spots, microangiomas, hemorrhages, and ...
Xiaodong Li +2 more
wiley +1 more source
Clinical and Translational Discovery, Volume 4, Issue 6, December 2024.Under GAAs, microglia are activated towards M1 (pro‐inflammatory) phenotype through direct and indirect ways. Microglia‐mediated neuroinflammation induce neuronal death, synaptic loss and dysmyelination in developing brain, which might be a key mechanism of neurocognitive deficits during neurodevelopment.
Xinyue Liang +4 more
wiley +1 more source
A Futile Redox Cycle Involving Neuroglobin Observed at Physiological Temperature
, 2015 Previous studies identifying the potential anti-apoptotic role of neuroglobin raise the question as to how cells might employ neuroglobin to avoid the apoptotic impact of acute hypoxia whilst also avoiding chronic enhancement of tumour formation. We show
Thomas Brittain, Anyang Liu
core +1 more source
Electroanalysis, Volume 36, Issue 12, December 2024.Abstract In medical diagnostics, variations in hemoglobin levels can reveal a variety of prevalent health conditions. Abnormal hemoglobin is known to be connected with diseases like anemia, diabetes, hematemesis, hematuria, and hemoglobinuria. Consequently, there is a significant demand for advanced detection technologies and precise methodologies to ...
Hilal Özçelik +5 more
wiley +1 more source
Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat. [PDF]
, 2014 Neuroglobin is a neuron-specific hexacoordinated globin capable of binding various ligands, including O2, NO, and CO, the biological function of which is still uncertain.
Giardina, Bruno +37 more
core +1 more source
Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases
Brain and Behavior, Volume 14, Issue 11, November 2024.Dexmedetomidine has demonstrated potent neuroprotective effects in a variety of brain disorders, and this may be achieved by inhibiting inflammatory responses, attenuating oxidative stress, reducing apoptosis and autophagy, and improving the immune microenvironment.
Zhenxing Tao, Pengpeng Li, Xudong Zhao
wiley +1 more source
Functional and sequence analysis of human neuroglobin gene promoter region
, 2011 Neuroglobin (Ngb), a recently found oxygen-binding protein belonging to the vertebrate globin family, is mainly expressed in neurons of brains and eyes.
Wei Zhang +11 more
core +1 more source