Results 61 to 70 of about 3,008 (200)

Prunus cerasoides Extract and Its Component Compounds Upregulate Neuronal Neuroglobin Levels, Mediate Antioxidant Effects, and Ameliorate Functional Losses in the Mouse Model of Cerebral Ischemia

open access: yesAntioxidants, 2021
Prunus cerasoides (PC) has been reported to have antimicrobial and anti-inflammatory properties, but its potential as a neuroprotective agent in a mouse model of cerebral ischemia has not been explored.
So-Dam Kim   +5 more
doaj   +1 more source

Is neuroglobin a signal transducer? [PDF]

open access: yesIUBMB Life, 2008
[No abstract available]
GIUFFRE', ALESSANDRO   +3 more
openaire   +3 more sources

Vesicular Rps6 Released by Astrocytes in an Experimental Model of AD Regulates Local Translation and Enhances Synaptic Integrity in Neurones

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover. Defects in protein homeostasis frequently lead to neuronal dysfunction and neurological disorders.
María Gamarra   +7 more
wiley   +1 more source

Development of a System for Biosynthesis, Isolation and Purification of the Holoform of Recombinant Human Neuroglobin and Its Characteristics

open access: yesRussian journal of bioorganic chemistry, 2023
An efficient system for the biosynthesis, isolation and purification of recombinant human neuroglobin has been developed and optimized, which makes it possible to produce protein in quantities sufficient to study its properties.
M. Semenova   +11 more
semanticscholar   +1 more source

Seizure Activity and Hypoxia Differentially Regulate Endogenous Neurotrophic Activin A and Neuroglobin Expression in the Immature Mouse Brain

open access: yesInternational Journal of Developmental Neuroscience, Volume 85, Issue 5, August 2025.
We investigated the regulatory effects of seizure‐induced excitotoxicity and acute hypoxia on the cytoprotective activin A and Ngb systems in the developing mouse brain. Our results demonstrate the differential regulation of Ngb and activin A as a function of time and type of injury and suggest their potential role as biomarkers of excitotoxic and ...
Clara Becker   +2 more
wiley   +1 more source

Conformational Dynamics in Neuroglobin [PDF]

open access: yesBiophysical Journal, 2011
Neuroglobin (Ngb) is a heme protein that belongs to the family of hexacoordinated hemoglobins. The physiological role of this protein is not well understood, but several plausible functions have been proposed such as oxygen carrier, oxygen sensor, NO scavenger and protectant against oxidative damage. To understand the mechanism of Ngb interactions with
Astudillo, Luisana   +4 more
openaire   +1 more source

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

open access: yesChemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile   +4 more
wiley   +1 more source

Carrier capability of halloysite nanotubes for the intracellular delivery of antisense PNA targeting mRNA of neuroglobin gene.

open access: yesJournal of Colloid and Interface Science
Peptide nucleic acid (PNA) is a DNA mimic that shows good stability against nucleases and proteases, forming strongly recognized complementary strands of DNA and RNA. However, due to its feeble ability to cross the cellular membrane, PNA activity and its
A. Falanga   +10 more
semanticscholar   +1 more source

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

open access: yesBritish Journal of Haematology, Volume 206, Issue 6, Page 1585-1592, June 2025.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs   +13 more
wiley   +1 more source

What is the function of neuroglobin? [PDF]

open access: yesJournal of Experimental Biology, 2009
SUMMARY For a long time, haemoglobin and myoglobin had been assumed to represent the only globin types of vertebrates. In 2000, however, we discovered a third globin type by mining the genome sequence data. Based on a preferential expression in the nervous system, this globin is referred to as neuroglobin. Despite nine years of research,
Thorsten, Burmester, Thomas, Hankeln
openaire   +2 more sources

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