Results 31 to 40 of about 3,008 (200)
Neural Regeneration Research, 2021 Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues.
Ciccone L. +3 more
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Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke
Pharmaceutics, 2020 Therapies against stroke can restore the blood supply but cannot prevent the ischemic damage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an important role in the neuro-regeneration process after stroke; however, the ...
Santos Blanco +7 more
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Insights into heme degradation and hydrogen peroxide-induced dimerization of human neuroglobin. [PDF]
Biosci RepIn this present study, we investigated the H2O2-induced oligomerization of wild-type human neuroglobin (hNgb) and of some selected variants (C46AC55A, Y44A, Y44F, Y44AC46AC55A, Y44AC46AC55A) to clarify how the process is affected by the Cys46/Cys55 ...
Cassiani A +4 more
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Does Neuroglobin Protect Against Stroke? Insights Into the Role of Neurovascular Unit Cells. [PDF]
Cell Mol NeurobiolIschemic stroke, a leading cause of disability and mortality, initiates a complex damage cascade within the neurovascular unit (NVU), leading to blood-brain barrier (BBB) disruption and neuroinflammation that severely exacerbates secondary injury ...
Peinado MÁ +8 more
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Neuroglobin Ligand Binding Kinetics [PDF]
IUBMB Life, 2004 AbstractNeuroglobin, cytoglobin, and hemoglobins from Drosophila melanogaster and Arabidopsis thaliana were studied for their ligand binding properties versus temperature. These globins have a common feature of being hexacoordinated (via the distal histidine) under deoxy conditions, displaying an enhanced amplitude for the alpha absorption band at 560 ...
Kiger, Laurent +8 more
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Neurobiology of Disease, 2021 Mitochondrial diseases are among the most prevalent groups of inherited neurological disorders, affecting up to 1 in 5000 adults. Despite the progress achieved on the identification of gene mutations causing mitochondrial pathologies, they cannot be ...
Hélène Cwerman-Thibault +9 more
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Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
Cells, 2021 Retinal neurodegeneration affects an increasing number of people worldwide causing vision impairments and blindness, reducing quality of life, and generating a great economic challenge.
Virginia Solar Fernandez +2 more
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Mitochondrial Mechanisms of Neuroglobin’s Neuroprotection [PDF]
Oxidative Medicine and Cellular Longevity, 2013 Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders. However, the underlying mechanisms of Ngb’s neuroprotection remain largely undefined. Mitochondria play critical roles in multiple physiological pathways including cell respiration, energy production,
Zhanyang Yu +2 more
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New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
Pharmaceutics, 2022 Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke ...
Santos Blanco +3 more
doaj +1 more source
Searching for Neuroglobin's role in the brain [PDF]
IUBMB Life, 2007 AbstractNeuroglobin is a small globin that plays an important role in the protection of brain neurons from ischemic and hypoxic injuries. The molecular mechanisms by which Ngb performs its physiological function are still under debate. Suggestions include oxygen storage and delivery, scavenging of NO and/or reactive oxygen species, oxygen sensing and ...
Nienhaus, Karin, Nienhaus, G. Ulrich
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