Targeting Retinal Neuroglial Vascular Unit Damage: Novel Therapeutic Strategies for Early-Stage Diabetic Retinopathy. [PDF]
J Diabetes ResDiabetic retinopathy (DR) is a prevalent chronic ocular complication of diabetes, which ranks as the leading cause of blindness in individuals aged 40 and above. Recent studies have demonstrated that neuroglial vascular unit (NGVU) injury leads to distinct fundus changes in DR, including exudates, cotton‐fluff spots, microangiomas, hemorrhages, and ...
Li X, Zhou H.
europepmc +2 more sources
New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
Pharmaceutics, 2022 Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke ...
Santos Blanco +3 more
doaj +1 more source
Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats [PDF]
, 2013 We hypothesized that targeting key points in the ischemic cascade with combined neuroglobin (Ngb) overexpression and c-jun N-terminal kinase (JNK) inhibition (SP600125) would offer greater neuroprotection than single treatment after in vitro hypoxia ...
Kremer, Eric J. +6 more
core +3 more sources
Genetic determinants of neuroglobin transcription [PDF]
neurogenetics, 2013 Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
R, Wang +4 more
openaire +2 more sources
Phylogeny of Echinoderm Hemoglobins. [PDF]
PLoS ONE, 2015 Recent genomic information has revealed that neuroglobin and cytoglobin are the two principal lineages of vertebrate hemoglobins, with the latter encompassing the familiar myoglobin and α-globin/β-globin tetramer hemoglobin, and several minor groups.
Ana B Christensen +9 more
doaj +1 more source
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System
Antioxidants, 2022 Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular ...
Daniela Giordano +2 more
doaj +1 more source
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating [PDF]
, 2019 Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection.
Anselmi, Massimiliano +10 more
core +4 more sources
Neuroglobin-overexpression reduces traumatic brain lesion size in mice [PDF]
, 2012 Background: Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries.
Changhong Xing +8 more
core +1 more source
A neuroglobin-overexpressing transgenic mouse [PDF]
Gene, 2007 Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan +6 more
openaire +2 more sources
EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin [PDF]
, 2014 Electron paramagnetic resonance (EPR) data reveal large differences between the ferric (C-)cyanide complexes of wild-type human neuroglobin (NGB) and its H64Q and F28L point mutants and the cyanide complexes of mammalian myo-and haemoglobin.
Dewilde, Sylvia +4 more
core +1 more source