Results 91 to 100 of about 9,131 (243)
Non‐Invasive Prenatal Diagnosis of Haemoglobinopathies: From Concept to Clinical Reality
Prenatal Diagnosis, EarlyView.ABSTRACT Haemoglobinopathies are the most prevalent monogenic disorders worldwide, contributing significantly to childhood morbidity and mortality. Preventive strategies, including carrier screening and prenatal diagnosis, have successfully reduced disease incidence in regions with established programmes.
Irene Leonidou +7 more
wiley +1 more source
, 2013 Nitrogen hyperfine and nuclear quadrupole components derived from the simulations for GLB-26 in comparison to other globins.
Bart P. Braeckman (294301) +11 more
core +1 more source
Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins
, 2013 Multimeric globins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric globins (e.g., myoglobin; Mb) usually are assumed to be non-allosteric.
M. Bolognesi +42 more
core +2 more sources
Studia Universitatis Babes-Bolyai Chemia, 2017 Several phenolic compounds belonging to different classes were comparatively analyzed for their ability to reduce ferryl forms of three non-symbiotic phytoglobins which were generated in situ by hydrogen peroxide and thus acting as enzymes.
Galaba NAUMOVA-LEȚIA +1 more
doaj +1 more source
Plastic and adaptive mitochondrial responses help face hypoxia events in a freshwater fish
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Hypoxic events (i.e. reduction of dissolved oxygen in water) are natural events, which intensity and frequency have been amplified by human activities. As oxygen fuels aerobic metabolism, species unable to avoid those events must maintain their functions through ...
Eugénie Dereuder +4 more
wiley +1 more source
Biological Research, 2007 In vitro suspension culture procedures for erythroid progenitor cells make it possible for us to obtain large cultures of erythrocyte populations for the investigation of globin gene switching.
XIN ZHANG, YAN-NI MA, JUN-WU ZHANG
doaj
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Lower testosterone concentrations in older men are associated with poorer health outcomes. Objective We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly ...
Bu B. Yeap +11 more
wiley +1 more source
Comparison of the structures of globins and phycocyanins: Evidence for evolutionary relationship
, 1990 Globins and phycocyanins are two classes of proteins with different function, different ligands, and no substantial sequence similarity, yet the conformations of their polypeptide chains show very similar folding patterns. Does this arise from a genuine,
Lesk A. M., PASTORE, ANNALISA
core +1 more source
British Journal of Haematology, EarlyView.In this trial, conducted in Kenya, Nigeria and Brazil, the resolution of leg ulcers was similar between the voxelotor and placebo arms. In the 12‐week blinded period, the number of sickle cell anaemia with crisis events was higher in the voxelotor arm compared to placebo.
Bernhards Ogutu +19 more
wiley +1 more source