Results 81 to 90 of about 9,131 (243)

Comparative genomics of neuroglobin reveals its early origins. [PDF]

PLoS ONE, 2012
Neuroglobin (Ngb) is a hexacoordinated globin expressed mainly in the central and peripheral nervous system of vertebrates. Although several hypotheses have been put forward regarding the role of neuroglobin, its definite function remains uncertain.
Jasmin Dröge, Amit Pande, Ella W Englander, Wojciech Makałowski   +3 more
doaj   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Template Activity for Globin and Non-Globin Protein Synthesis in Reticulocytes

Journal of Biological Chemistry, 1972
Factors which control the rate of synthesis of two distinct classes of protein, globin and non-globin proteins, by free reticulocyte ribosomes have been investigated. Three different inhibitors of protein synthesis, puromycin, cycloheximide, and hydroxylamine, were more effective in inhibiting the synthesis of globin than of non-globin protein by free ...
S I, Bulova, E R, Burka
openaire   +2 more sources

Oxygen binding properties of non-mammalian nerve globins [PDF]

, 2006
Oxygen-binding globins occur in the nervous systems of both invertebrates and vertebrates. While the function of invertebrate nerve haemoglobins as oxygen stores that extend neural excitability under hypoxia has been convincingly demonstrated, the ...
Hankeln, Tom, Hundahl, Christian, Dewilde, S., Dewilde, Sylvia, Fago, A., Sylvia Dewilde, Christian Hundahl, Angela Fago, Burmester, Thorsten, Luc Moens, Fago, Angela, Burmester, T., Hankeln, T., Tom Hankeln, Moens, L., Roy E. Weber, Hundahl, C., Weber, R.E., Weber, Roy E., Moens, Luc, Thorsten Burmester   +20 more
core   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Mammalian nerve globins in search of functions

, 2014
Nerve globins are present in nonvertebrates and vertebrates, the first nerve globin having been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. Later, in 2000, the first vertebrate nerve globin, named neuroglobin (Ngb),
ASCENZI, Paolo, Maria Marino, MARINO, Maria, Gustincich, Stefano, Stefano Gustincich, Paolo Ascenzi, Gustincich S, Ascenzi P., Marino M.   +8 more
core   +1 more source

Nitrite binding to globins: linkage isomerism, EPR silence and reductive chemistry [PDF]

, 2014
The nitrite adducts of globins can potentially bind via O- or N- linkage to the heme iron. We have used EPR (electron paramagnetic resonance) and DFT (density functional theory) to explore these binding modes to myoglobin and hemoglobin.
Svistunenko, DA, Silaghi-Dumitrescu, R, Cooper, CE, Bischin, C, Scurtu, F, Cioloboc, D   +5 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Comparison of MLPA Method for Detection of Known and Unknown Deletions in Beta Globin Gene Cluster with Old Methods (REAL-TIME, RFLP, Gap-PCR)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and Objectives Thalassaemia is one of the most common single gene disorders, which is most prevalent in the Mediterranean, the Middle East, Indian subcontinent (malaria belt). One of the mutations that result in Thalassaemia is the deletion in
R R Alimohammadi, M Raiesi, A Ebrahimi, S Fallah, S Kianfar, M Masoudifar, S Jamali, S Babashah, M Karimipour, R Mahdian, S Zeinali   +10 more
doaj  

Canalization of globins in the adaptive evolution of birds

Avian Research
The globin superfamily, central to oxygen (O2) cascade dynamics, exemplifies how canalization—evolutionary stabilization of phenotypic traits—enables vertebrates to thrive in extreme environments.
Xiaojia Zhu, Le Yang, Quanjian Tao, Xiran Wang, Ghulam Nabi, Fumin Lei, Xiaoping Yu, Dongming Li   +7 more
doaj   +1 more source