Results 61 to 70 of about 8,559 (239)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Representative Genes masked by globins and unmasked in PAX-GR.

, 2013
Representative Genes masked by globins and unmasked in PAX-GR.
Peter J. Munson (17525), Nalini Raghavachari (41488), Xiuli Xu (371238), Mark T. Gladwin (167745)   +3 more
core   +1 more source

Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda [PDF]

, 2018
Globins are among the best investigated proteins in biological and medical sciences and represent a prime tool for the study of the evolution of genes and the structure- function relationship of proteins.
Bracke, An, An Bracke, David Hoogewijs, Dewilde, Sylvia, Sylvia Dewilde, Hoogewijs, David   +5 more
core   +1 more source

Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins.

, 2013
Multimeric globins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric globins (e.g., myoglobin; Mb) usually are assumed to be non-allosteric.
M. Bolognesi, COLETTA, MASSIMILIANO, Polticelli F, Marini, Stefano, M. Coletta, M. Nardini, Wilson, M, F. Polticelli, Reeder, B, Nardini, M, Reeder BJ, Bolognesi, M, Pesce, Alessandra, Bolognesi M, P. Ascenzi, B. J. Reeder, Marino M, Marini S, MARINI, S, Ascenzi, Paolo, Gioia M, Coletta, M, Marino, Maria, M. Gioia, Polticelli, F, M. T. Wilson, Ascenzi P, Bolognesi, Martino, Wilson M.T., Polticelli, Fabio, M. Marino, A. Pesce, Gioia, Magda, Nardini, Marco, Wilson, M., Gioia, M, Wilson, Michael T, S. Marini, Marino, M, Coletta M, Coletta, Massimo, Reeder, Brandon J, Ascenzi, P, Nardini M, Pesce, A   +44 more
core   +2 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Characterization and Comparative Immunoreactivity of Antibody to Newt (T. cristatus) Globins [PDF]

, 1984
1. Rabbit antisera to newt (T. cristatus) globin were produced by repeated injections of globin and antiglobin antibodies purified by chromatography on globin-Sepharose 4B. 2.
Kowalski, Louis A.,, Grasso, Joseph A.,, Walsh, Anne W., Grasso, Joseph A., Mackin, William,, Merrow, Martha,, Walsh, Anne W.,, Kowalski, Louis A., Mackin, William, Paulekus, Wayne, Merrow, Martha, Paulekus, Wayne,   +11 more
core   +1 more source

Neuroglobin and cytoglobin: two new members of globin family

Revista Brasileira de Hematologia e Hemoterapia, 2011
The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui, Marcio Francisco Colombo   +1 more
doaj   +1 more source

Iron metabolic pathways in the processes of sponge plasticity.

PLoS ONE, 2020
The ability to regulate oxygen consumption evolved in ancestral animals and is intrinsically linked to iron metabolism. The iron pathways have been intensively studied in mammals, whereas data on distant invertebrates are limited.
Alexander D Finoshin, Kim I Adameyko, Kirill V Mikhailov, Oksana I Kravchuk, Anton A Georgiev, Nicolay G Gornostaev, Igor A Kosevich, Victor S Mikhailov, Guzel R Gazizova, Elena I Shagimardanova, Oleg A Gusev, Yulia V Lyupina   +11 more
doaj   +1 more source

Clinical Validation of Four Point‐of‐Care High‐Risk HPV Assays, Including Two Reduced‐Valency Assays, for Cervical Cancer Screening in Low‐Resource Settings

International Journal of Cancer, EarlyView.
High‐risk human papillomavirus (hrHPV) testing improves cervical cancer screening by facilitating earlier detection and prevention. In low‐resource settings, however, cost and increased referrals limit its use. At the same time, many new and more affordable assays lack validation.
Neerja Bhatla, MaryLuz Rol, Seema Singhal, Showket Hussain, Anushree Patil, Pranay Tanwar, Shalini Singh, Vikrant M. Bhor, Kiran Munne, Richa Vashishtha, Shachi Vashist, Eric Lucas, Richard Muwonge, Arianis Tatiana Ramírez, Anju Singh, Vikas Khan, Jyoti Rani, Nasera Firdausi, Sandeep Sisodiya, Rutuja Wakchaure, María Alejandra Picconi, Alejandro Calderón, Margo Bell, Annemie De Smet, Alex Vorsters, Gary M. Clifford, Madhavi Chandra, Jitendra Kumar, Partha Basu   +28 more
wiley   +1 more source

Monodisperse 130 kDa and 260 kDa Recombinant Human Hemoglobin Polymers as Scaffolds for Protein Engineering of Hemoglobin-Based Oxygen Carriers

Journal of Functional Biomaterials, 2012
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β globins has been expressed as a soluble protein in E. coli. The sequence of the single chain tetra-α is: αI-Gly-αII-(SerGlyGly)5Ser-αIII-Gly-αIV.
Jacqueline F. Aitken, Spencer J. Anthony-Cahill, Douglas D. Lemon, Michael P. Doyle, David A. Marquardt, Jeffrey S. Davidson, Janet K. Epp   +6 more
doaj   +1 more source