Results 51 to 60 of about 45,771 (276)
ACTIVIN RECEPTOR LIGAND FOR THR TREATMENT OF BETA-THALASSEMIA: a SERENDIPITOUS DISCOVERY
Mediterranean Journal of Hematology and Infectious Diseases, 2020 b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins.
Irene Motta +4 more
doaj +1 more source
Reactions of HNO with Metal Porphyrins: Underscoring the Biological Relevance of HNO [PDF]
, 2014 Azanone (1 HNO, nitroxyl) shows interesting yet poorly understood chemical and biological effects. HNO has some overlapping properties with nitric oxide (NO), sharing its biological reactivity toward heme proteins, thiols, and oxygen.
Bikiel, Damian Ezequiel +4 more
core +1 more source
EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin [PDF]
, 2014 Electron paramagnetic resonance (EPR) data reveal large differences between the ferric (C-)cyanide complexes of wild-type human neuroglobin (NGB) and its H64Q and F28L point mutants and the cyanide complexes of mammalian myo-and haemoglobin.
Dewilde, Sylvia +4 more
core +1 more source
An Interplay of Gases: Oxygen and Hydrogen in Biological Systems
OxygenProduced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS).
Grace Russell +2 more
doaj +1 more source
Nitrophorins and nitrobindins: structure and function
Biomolecular Concepts, 2017 Classical all α-helical globins are present in all living organisms and are ordered in three lineages: (i) flavohemoglobins and single domain globins, (ii) protoglobins and globin coupled sensors and (iii) truncated hemoglobins, displaying the 3/3 or the
De Simone Giovanna +3 more
doaj +1 more source
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating [PDF]
, 2019 Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection.
Anselmi, Massimiliano +10 more
core +4 more sources
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Structural interpretation of the amino acid sequence of a second domain from the Artemia covalent polymer globin [PDF]
, 1990 Artemia has a complex extracellular hemoglobin of Mr 260,000 comprising two globin chains (Mr 130,000) each of which is a polymer of eight covalently linked domains of Mr 16,000.
Alard, Philippe +8 more
core +1 more source
Advanced Materials, EarlyView.A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee +8 more
wiley +1 more source
BMC Evolutionary Biology, 2012 Background For a long time the presence of respiratory proteins in most insects has been considered unnecessary. However, in recent years it has become evident that globins belong to the standard repertoire of the insect genome.
Gleixner Eva +4 more
doaj +1 more source