Results 41 to 50 of about 45,771 (276)

Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling [PDF]

, 2014
Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN.
Bidon Chanal, Axel, Datta, H., Dikshit, Kanak L., Estrin, Dario Ariel, Hade, Mangesh Dattu, Luque, F. Javier, Marti, Marcelo Adrian, Oliveira, Ana, Parkesh, R., Petruk, Ariel Alcides, Sethi, Deepti, Singh, Sandeep, Thakur, Naveen   +12 more
core   +2 more sources

Funneled angle landscapes for helical proteins [PDF]

, 2020
We use crystallographic data for four helical iron proteins (cytochrome c-b₅₆₂, cytochrome c′, sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states.
Garza-López, Roberto A., Gray, Harry B., Kozak, John J.   +2 more
core   +1 more source

Gelling Properties of Globin-Succinylated Globin Conjugates.

NIPPON SHOKUHIN KOGYO GAKKAISHI, 1993
2種類のグロビン-サクシニル化グロビン複合体(CMHTとCUT)を調製し,各複合体のゲル特性について検討した.(1) CMHTはGの配合比率が高くなる程ゲル形成pHは中性の方へ拡大した.例えば, GとSGの配合率が3:7の場合,ゲル形成pHは2.0であったが,G:SG=9:1の場合,ゲルはpH 2.0～3.5の範囲で形成された.一方, G:SGの配合比率が7:3と9:1のCUTの場合,ゲル形成pHは極めて狭い範囲に限定された.(2) ゲルの透明度はCMHT, CUTともにより酸性側で高く,また,グロビンの配合比率が高くなる程透明度も高くなる傾向を示した.(3) 複合体ゲルのゲル強度を測定した. CMHTの場合, G:SG=5:5 (pH 2.0)で高いゲル強度が得られた.
Yuji MIYAGUCHI, Toyoo NAKAMURA, Satoru TAKABATAKE, Masami YONEKURA, Masakazu TSUTSUMI   +4 more
openaire   +2 more sources

Zebrafish Globin Switching Occurs in Two Developmental Stages and Is Controlled by the LCR [PDF]

, 2014
Globin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based on the completed genomic ...
de Jong, Jill L.O., DiBiase, Anthony, Ganis, Jared Jason, Hsia, Nelson, Jia, Zhiying, Lambert, Janelle S., Sabo, Peter J., Sandstrom, Richard, Stamatoyannopoulos, John A., Trompouki, Eirini, Weaver, Molly, Zhou, Yi, Zon, Leonard Ira   +12 more
core   +1 more source

Engineered chimeras reveal the structural basis of hexacoordination in globins: a case study of neuroglobin and myoglobin.

Biochimica et Biophysica Acta, 2015
BACKGROUND Myoglobin (Mb) and neuroglobin (Ngb) are representative members of pentacoordinated and bis-histidyl, hexacoordinated globins. In spite of their low sequence identity, they show surprisingly similar three-dimensional folds.
Ignacio Boron, Ignacio Boron, L. Capece, Francesca Pennacchietti, D. Wetzler, D. Wetzler, S. Bruno, S. Abbruzzetti, Lucía B. Chisari, F. Luque, C. Viappiani, M. Marti, M. Marti, D. Estrin, D. Estrin, A. Nadra, A. Nadra   +16 more
semanticscholar   +1 more source

Hemoglobin switching in mice carrying the Klf1^Nan variant

Haematologica, 2020
Haploinsufficiency for transcription factor KLF1 causes a variety of human erythroid phenotypes, such as the In(Lu) blood type, increased HbA2 levels, and hereditary persistence of fetal hemoglobin. Severe dominant congenital dyserythropoietic anemia IV
Anne Korporaal, Nynke Gillemans, Steven Heshusius, Ileana Cantú, Emile van den Akker, Thamar B. van Dijk, Marieke von Lindern, Sjaak Philipsen   +7 more
doaj   +1 more source

Globins Scavenge Sulfur Trioxide Anion Radical*

Journal of Biological Chemistry, 2015
Background: Sulfite, an intermediate in sulfur metabolism, can be oxidized to the potentially toxic sulfur trioxide anion radical (STAR). Results: Diverse globins efficiently reduced STAR in vitro, and flavohemoglobin protected yeast from STAR toxicity ...
P. R. Gardner, D. P. Gardner, A. Gardner
semanticscholar   +1 more source

Redox-Regulation of α-Globin in Vascular Physiology

Antioxidants, 2022
Interest in the structure, function, and evolutionary relations of circulating and intracellular globins dates back more than 60 years to the first determination of the three-dimensional structure of these proteins.
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve   +7 more
doaj   +1 more source

Engineering Globin Gene Expression [PDF]

Molecular Therapy - Methods & Clinical Development, 2019
Hemoglobinopathies, including sickle cell disease and thalassemia, are among the most common inherited genetic diseases worldwide. Due to the relative ease of isolating and genetically modifying hematopoietic stem and progenitor cells, recent gene editing and gene therapy strategies have progressed to clinical trials with promising outcomes; however ...
Rachael Davis, Aishwarya Gurumurthy, Mir A. Hossain, Eliot M. Gunn, Jörg Bungert   +4 more
openaire   +3 more sources

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene

Haematologica, 2020
The human fetal γ-globin gene is repressed in the adult stage through complex regulatory mechanisms involving transcription factors and epigenetic modifiers.
Cristina Fugazza, Gloria Barbarani, Sudharshan Elangovan, Maria Giuseppina Marini, Serena Giolitto, Isaura Font-Monclus, Maria Franca Marongiu, Laura Manunza, John Strouboulis, Claudio Cantù, Fabio Gasparri, Silvia M.L. Barabino, Yukio Nakamura, Sergio Ottolenghi, Paolo Moi, Antonella Ellena Ronchi   +15 more
doaj   +1 more source