Results 41 to 50 of about 9,131 (243)

ACTIVIN RECEPTOR LIGAND FOR THR TREATMENT OF BETA-THALASSEMIA: a SERENDIPITOUS DISCOVERY

Mediterranean Journal of Hematology and Infectious Diseases, 2020
b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins.
Irene Motta, Valentina Brancaleoni, Isabella Nava, Paola Delbini, Lorena Duca   +4 more
doaj   +1 more source

Catalytic peroxidation of nitrogen monoxide and peroxynitrite by globins

, 2009
Globins are generally considered as carriers of diatomic gaseous ligands (e.g., O2 and NO) in metazoa. Recently, the (pseudo-)enzymatic activity of globins towards reactive nitrogen and oxygen species has been elucidated. In particular, some globins (e.g.
Ciaccio Chiara, CASELLA, LUIGI, Ciaccio C., COLETTA M, Visca Paolo, Visca P., DE MARINIS E, ASCENZI, Paolo, VISCA, PAOLO, De Marinis Elisabetta, Coletta Massimo, CASELLA L, Ascenzi Paolo, Casella L., Ascenzi P., De Marinis E., CIACCIO C, Coletta M.   +17 more
core   +1 more source

Comparison of Evolutionary Relationships between Branchiostoma floridae, Ciona intestinalis, and Homo sapiens Globins Provide Evidence of Gene Co-Option and Convergent Evolution

, 2023
Globins have been studied as model proteins to elucidate the principles of protein evolution. This was achieved by understanding the relationship between amino acid sequence, three-dimensional structure, physicochemical properties, and physiological ...
Nanako Yano, Hirosi Yamaguchi, Takahito Nishikata, Toshifumi Minamoto, Toshiyuki Goto   +4 more
core   +1 more source

Globin genes on the move [PDF]

Journal of Biology, 2008
Recent data published in BMC Biology from the globin gene clusters in platypus, together with data from other species, show that beta-globin genes transposed from one chromosomal location to another. This resolves some controversies about vertebrate globin gene evolution but ignites new ones.
openaire   +2 more sources

An Interplay of Gases: Oxygen and Hydrogen in Biological Systems

Oxygen
Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS).
Grace Russell, Jennifer May, John T. Hancock   +2 more
doaj   +1 more source

Nitrophorins and nitrobindins: structure and function

Biomolecular Concepts, 2017
Classical all α-helical globins are present in all living organisms and are ordered in three lineages: (i) flavohemoglobins and single domain globins, (ii) protoglobins and globin coupled sensors and (iii) truncated hemoglobins, displaying the 3/3 or the
De Simone Giovanna, Ascenzi Paolo, di Masi Alessandra, Polticelli Fabio   +3 more
doaj   +1 more source

Perception of Parents of Children suffering from Thalassemia in Karimnagar District of Telangana state in India

International Journal of Medical Sciences and Academic Research, 2023
Introduction : Thalassemias are a group of inheritable hemoglobinopathies where abnormal hemoglobin is synthesized leading to decreased hemoglobin levels in the body.
Dr. Atul Gopal Agrawal, Dr. Noori Afifa, Dr. Gantla Akhil, Snigdha Mishra, Dr. Ankita Agrawal
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

The diversity of globin‐coupled sensors [PDF]

FEBS Letters, 2003
The recently discovered globin‐coupled sensors (GCSs) are heme‐containing two‐domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi‐domain C‐terminal transmitters through a search of the complete and incomplete microbial genome datasets.
Freitas, Tracey Allen K, Hou, Shaobin, Alam, Maqsudul   +2 more
openaire   +2 more sources