Results 1 to 10 of about 108,933 (325)

The Glomerular Filtration Barrier: Components and Crosstalk

International Journal of Nephrology, 2012
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules.
Madhav C. Menon, Peter Y. Chuang, Cijiang John He   +2 more
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Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition. [PDF]

PLoS ONE, 2011
Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli.
Brooke M Steenhard, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Glen K Andrews, Kenneth R Peterson, Dale R Abrahamson   +7 more
doaj   +1 more source

Pattern of collagen IV expression in glomerular and mesenchymal basement membrane during fetal and postnatal period of Balb/c Mice [PDF]

Journal of Cell and Molecular Research, 2009
Basement membrane of glomerular mesangium (BMG) is a thin membrane which helps to support the capillary loops in a renal glomerulus and type IV collagen is require for complete BM formation during glomerulogenesis. In this investigation specific antibody
Mohammad Reza Nikravesh, M Jalali, MH Karimfar, AA Moeen, Saeedi Nejat Sh, Sh Mohammadi, H Rafighdoust   +6 more
doaj   +1 more source

The role of heparan sulfate in the glomerular basement membrane [PDF]

Kidney International, 2008
Recent studies, including those by van den Hoven and colleagues, have challenged the classic negative-charge theory of glomerular filtration. However, the possibility remains that heparan sulfate in the glomerular basement membrane plays a role in maintaining the glomerular filtration barrier.
Ashio Yoshimura, K. Kimata, Hiroyuki Morita   +2 more
openaire   +3 more sources

Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome

Acta Dermato-Venereologica, 2019
Nail-patella syndrome is an autosomal dominant disorder characterized by nail dysplasia and skeletal anomaly. Some patients have been shown to have ultrastructural abnormalities of the glomerular basement membrane that result in nephrosis.
Satoru Shinkuma, Hideki Nakamura, Manami Maehara, Shota Takashima, Toshifumi Nomura, Yasuyuki Fujita, Satoshi Hasegawa, Kazuko C. Sato-Matsumura, Riichiro Abe, Hiroshi Shimizu   +9 more
doaj   +1 more source

Studies on Glomerular Basement Membrane. 1. Isolation and Chemical Analysis of Normal Glomerular Basement Membrane.

Experimental Biology and Medicine, 1966
SummaryA method has been described for obtaining isolated human glomerular basement membrane. Evidence for the purity of the isolated GBM includes electron microscopic and chemical data. Some of the membrane constituents, in particular hydroxypro-line, aminosugars, sialic acid, neutral sugars, and lipids have been identified.
R. P. Misra, L. B. Berman
openaire   +3 more sources

An In Vitro Model of the Glomerular Capillary Wall Using Electrospun Collagen Nanofibres in a Bioartificial Composite Basement Membrane

PLoS ONE, 2011
The filtering unit of the kidney, the glomerulus, contains capillaries whose walls function as a biological sieve, the glomerular filtration barrier.
Sadie C. Slater, V. Beachley, T. Hayes, Daming Zhang, G. Welsh, M. Saleem, P. Mathieson, X. Wen, B. Su, S. Satchell   +9 more
semanticscholar   +1 more source

Effects of a Novel COL4A3 Homozygous/Heterozygous Splicing Mutation on the Mild Phenotype in a Family With Autosomal Recessive Alport Syndrome and a Literature Review

Molecular Genetics & Genomic Medicine
Background Alport syndrome involves chronic progressive kidney failure and extrarenal organ damage caused by COL4A3, COL4A4, and COL4A5 mutations. Methods We initially discerned a COL4A3 splicing mutation via next‐generation sequencing.
Dan Chen, Li Zhang, Jing Rao, Yan Zhou, Lujun Dai, Songsong Huang, Chunxia Yang, Qiuhan Bian, Tao Zhang, Xiaoyan Yang   +9 more
doaj   +1 more source

Basement Membrane Defects in Genetic Kidney Diseases

Frontiers in Pediatrics, 2018
The glomerular basement membrane (GBM) is a specialized structure with a significant role in maintaining the glomerular filtration barrier. This GBM is formed from the fusion of two basement membranes during development and its function in the filtration
C. Chew, R. Lennon
semanticscholar   +1 more source

One case of anti-glomerular basement membrane disease with serum circulating antibodies tested by ELISA to be negative

Linchuang shenzangbing zazhi, 2020
病例资料患者,男,38岁,因"痰中带血1个月"于2018年7月12日入院。入院前1个月,患者无明显诱因出现暗红色血痰,量少,咳2～3口,不伴有发热、胸闷、气紧,于2018年6月7日到广元市人民医院门诊就诊,查胸部CT示双肺多发渗出灶,未予以处理。此后患者未再出现痰中带血 ...
HAO Yu, QIN Wei
doaj