Results 71 to 80 of about 33,604 (226)

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Effects of a Novel COL4A3 Homozygous/Heterozygous Splicing Mutation on the Mild Phenotype in a Family With Autosomal Recessive Alport Syndrome and a Literature Review

Molecular Genetics & Genomic Medicine
Background Alport syndrome involves chronic progressive kidney failure and extrarenal organ damage caused by COL4A3, COL4A4, and COL4A5 mutations. Methods We initially discerned a COL4A3 splicing mutation via next‐generation sequencing.
Dan Chen, Li Zhang, Jing Rao, Yan Zhou, Lujun Dai, Songsong Huang, Chunxia Yang, Qiuhan Bian, Tao Zhang, Xiaoyan Yang   +9 more
doaj   +1 more source

Never say never

Journal of Hospital Medicine, EarlyView.
Gurpreet Dhaliwal, Jagmeet Dhingra, Tom Fraser, Leal Herlitz, James Pile   +4 more
wiley   +1 more source

Fibroblast‐derived neuropilin 1 alleviates renal fibrosis progression

The Journal of Pathology, Volume 268, Issue 2, Page 127-134, February 2026.
Abstract Chronic kidney disease (CKD) is a major global health challenge affecting over 10% of the adult population. A hallmark of CKD progression is the transdifferentiation of kidney fibroblasts into extracellular matrix‐producing myofibroblasts, a key mechanism involved in the decline of kidney function and the development of kidney failure ...
Yunzhu Shen, Sandrine Placier, Liliane Louedec, Perrine Frère, Sophie Vandermeersch, Stefanny Figueroa, Hélène François, Christos E Chadjichristos, Camille Cohen, Christos Chatziantoniou, Amélie Calmont   +10 more
wiley   +1 more source

Nanoscale protein architecture of the kidney glomerular basement membrane

eLife, 2013
In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and functional roles in essentially all organs, so understanding ECM protein organization in health and disease remains an important goal.
Hani Suleiman, Lei Zhang, Robyn Roth, John E Heuser, Jeffrey H Miner, Andrey S Shaw, Adish Dani   +6 more
doaj   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

One case of anti-glomerular basement membrane disease with serum circulating antibodies tested by ELISA to be negative

Linchuang shenzangbing zazhi, 2020
病例资料患者,男,38岁,因"痰中带血1个月"于2018年7月12日入院。入院前1个月,患者无明显诱因出现暗红色血痰,量少,咳2～3口,不伴有发热、胸闷、气紧,于2018年6月7日到广元市人民医院门诊就诊,查胸部CT示双肺多发渗出灶,未予以处理。此后患者未再出现痰中带血 ...
HAO Yu, QIN Wei
doaj  

Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies

European Journal of Case Reports in Internal Medicine, 2017
A young male patient with rapidly progressive and life-threatening pulmonary haemorrhage due to anti-glomerular basement membrane (anti-GBM) antibody disease without renal involvement repeatedly tested negative for serum anti-GBM antibodies.
Tjitske Berends-De Vries, Susan Boerma, Joan Doornabal, Bert Dikkeschei, Coen Stegeman, Thiemo Veneman   +5 more
doaj   +1 more source

Studies on Glomerular Basement Membrane. 1. Isolation and Chemical Analysis of Normal Glomerular Basement Membrane.

Experimental Biology and Medicine, 1966
SummaryA method has been described for obtaining isolated human glomerular basement membrane. Evidence for the purity of the isolated GBM includes electron microscopic and chemical data. Some of the membrane constituents, in particular hydroxypro-line, aminosugars, sialic acid, neutral sugars, and lipids have been identified.
R P, Misra, L B, Berman
openaire   +2 more sources

A membranous nephropathy variant mimicking minimal change disease

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed ‘MCD‐like MN’. Patients with histologically confirmed MN showing sparse and segmental subepithelial electron‐dense deposits (EDD) but clinically resembling MCD were ...
Chuqi Pan, Silin Xiang, Mengya Jiang, Yuan Li, Biao Huang, Tian Ye, Yuanyuan Du, Xuanli Tang, Yuan Yuan   +8 more
wiley   +1 more source