Results 81 to 90 of about 107,331 (315)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Targeting kidney mesangium by nanoparticles of defined size [PDF]

, 2011
Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of ...
C. H. J. Choi, Chen, Choi, Davis, Davis, J. E. Zuckerman, Kanwar, Lahdenkari, Luft, M. E. Davis, Nurkiewicz, Ogawa, P. Webster, Peer, Ruckerl, Schipper, Schreiner, Soo Choi, Tan, Zimmermann   +19 more
core   +2 more sources

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
wiley   +1 more source

Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]

, 2016
Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat, Akgul, Nilgun, Altunkaynak, Berrin Zuhal, Altunkaynak, Muhammed Eyup, Deniz, Omur Gulsum, Unal, Deniz   +5 more
core   +1 more source

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury

Arthritis &Rheumatology, EarlyView.
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

The Glomerular Filtration Barrier: Components and Crosstalk

International Journal of Nephrology, 2012
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules.
Madhav C. Menon, Peter Y. Chuang, Cijiang John He   +2 more
doaj   +1 more source

Rituximab in anti-glomerular basement membrane disease.

QJM : monthly journal of the Association of Physicians, 2012
The role of rituximab has expanded beyond the treatment of non-Hodgkins lymphoma,1 to include successful management of rheumatoid arthritis,2 systemic lupus erythematosus,3 anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis4 and primary ...
Y. Shah, A. Mohiuddin, C. Sluman, I. Daryanani, T. Ledson, A. Banerjee, A. Crowe, P. Mcclelland   +7 more
semanticscholar   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

The Journal of Pathology, EarlyView.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk, Guolu Tang, Arno R Bourgonje, Wilfred F A den Dunnen, Jan‐Luuk Hillebrands, Harry van Goor   +5 more
wiley   +1 more source

Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]

, 2014
Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core   +6 more sources

Distribution of basement membrane antigens in glomeruli of mice with autoimmune glomerulonephritis. [PDF]

, 1986
peer reviewedGlomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glomerular basement membrane. The glomerular basement membranes of nephritic animals were observed to develop subepithelial extensions, "spikes."
Andres, G., Brentjens, J. R., Foidart, Jean-Michel, Martin, G. R., Martinez-Hernandez, A., Matsuo, S.   +5 more
core   +1 more source