Results 1 to 10 of about 77,535 (377)

Glomerulus Classification and Detection Based on Convolutional Neural Networks

Journal of Imaging, 2018
Glomerulus classification and detection in kidney tissue segments are key processes in nephropathology used for the correct diagnosis of the diseases. In this paper, we deal with the challenge of automating Glomerulus classification and detection from ...
Jaime Gallego, Anibal Pedraza, Arvydas Laurinavicius   +2 more
exaly   +4 more sources

Biomimetic models of the glomerulus

Nature Reviews Nephrology, 2022
The use of biomimetic models of the glomerulus has the potential to improve our understanding of the pathogenesis of kidney diseases and to enable progress in therapeutics. Current in vitro models comprise organ-on-a-chip, scaffold-based and organoid approaches.
Marta G Valverde, Kianti P Figler, Joseph V Bonventre   +2 more
exaly   +6 more sources

MLP-UNet: Glomerulus Segmentation

IEEE Access, 2023
Glomerulus segmentation in kidney tissue segments is a crucial nephropathology process used to diagnose renal diseases effectively. This study proposes a novel and robust application of MLP (Multi-Layer Perceptron) based architectures for the ...
Franchis N. Saikia, Yuji Iwahori, Taisei Suzuki, M. K. Bhuyan, Aili Wang, Boonserm Kijsirikul   +5 more
doaj   +2 more sources

Co-Culture of Glomerular Endothelial Cells and Podocytes in a Custom-Designed Glomerulus-on-a-Chip Model Improves the Filtration Barrier Integrity and Affects the Glomerular Cell Phenotype

Biosensors, 2023
Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes) is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the glomerular filtration barrier.
Daan C. ‘t Hart, Dilemin Yildiz, Valentina Palacio-Castañeda, Lanhui Li, Burcu Gumuscu, Roland Brock, Wouter P. R. Verdurmen, Johan van der Vlag, Tom Nijenhuis   +8 more
doaj   +2 more sources

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Micromachines, 2021
Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye, Rohan Bhattacharya, Xingrui Mou   +2 more
exaly   +2 more sources

Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset. [PDF]

, 2010
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function.
Anders, Hans-Joachim, Cohen, Clemens D., Edenhofer, Ilka, Eichinger, Felix, Kretzler, Matthias, Lindenmeyer, Maja T., Mattinzoli, Deborah, Rastaldi, Maria P., Sen, Kontheari   +8 more
core   +11 more sources

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

Nature Communications, 2019
In this work we model the glomerular filtration barrier, the structure responsible for filtering the blood and preventing the loss of proteins, using human podocytes and glomerular endothelial cells seeded into microfluidic chips.
Astgik Petrosyan, Paolo Cravedi, Valentina Villani   +2 more
exaly   +2 more sources

A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v

eLife, 2018
Using FIB-SEM we report the entire synaptic connectome of glomerulus VA1v of the right antennal lobe in Drosophila melanogaster. Within the glomerulus we densely reconstructed all neurons, including hitherto elusive local interneurons.
Jane Anne Horne, Carlie Langille, Sari McLin, Meagan Wiederman, Zhiyuan Lu, C Shan Xu, Stephen M Plaza, Louis K Scheffer, Harald F Hess, Ian A Meinertzhagen   +9 more
doaj   +2 more sources

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

Scientific Reports, 2016
Glomerular hypertension is an important factor exacerbating glomerular diseases to end-stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in hypertensive and diabetic nephropathy). The precise mechanism of glomerular
Mengying Zhou
exaly   +2 more sources

Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus

PLoS ONE, 2018
Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation.
Madhusudan Venkatareddy, Sanjeevkumar R Patel, Puneet Garg   +2 more
exaly   +2 more sources