Results 91 to 100 of about 40,034 (308)

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

The Glomerulus-Revisited

Microscopy and Microanalysis, 2001
Abstract In the embryologic development of the nephron, the glomerular tuft (renal corpuscle) and the excretory tubules develop from two distinct embryologic origins or anlagen. Nephrotomes constitute the earliest formation of the excretory tubules and appear first as segmentally arranged cell clusters, which grow and become canalized ...
openaire   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

Antinephritic Effect of Prostaglandin E1 on Serum Sickness Nephritis in Rats (5). Effect of PGE1 on Disposal of Heat-Aggregated Bovine Serum Albumin in the Glomerulus

, 1988
Tadashi Nagamatsu, Yoshio Suzuki
openalex   +2 more sources

Association of high vibration perception threshold with reduced renal function in patients with type 2 diabetes

Frontiers in Endocrinology
ObjectiveTo investigate the correlation between vibration sensory threshold (VPT) and renal function, including glomerulus and renal tubule, in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 1274 patients with T2DM who were enrolled in ...
Yongze Zhang, Yongze Zhang, Yongze Zhang, Yongze Zhang, Yongze Zhang, Yongze Zhang, Biao Zheng, Biao Zheng, Biao Zheng, Biao Zheng, Biao Zheng, Biao Zheng, Yimei Li, Yimei Li, Yimei Li, Yimei Li, Yimei Li, Yimei Li, Ximei Shen, Ximei Shen, Ximei Shen, Ximei Shen, Ximei Shen, Ximei Shen, Lingning Huang, Lingning Huang, Lingning Huang, Lingning Huang, Lingning Huang, Lingning Huang, Fengying Zhao, Fengying Zhao, Fengying Zhao, Fengying Zhao, Fengying Zhao, Fengying Zhao, Sunjie Yan, Sunjie Yan, Sunjie Yan, Sunjie Yan, Sunjie Yan, Sunjie Yan   +41 more
doaj   +1 more source

Adenoviral E4 Gene Stimulates Secretion of Pigmental Epithelium Derived Factor (PEDF) that Maintains Long-term Survival of Human Glomerulus-derived Endothelial Cells [PDF]

, 2012
Marina Jerebtsova, Namita Kumari, Yuri Obuhkov, Sergeï Nekhai   +3 more
openalex   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, EarlyView.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Genetic and environmental factors associated with alteration of filtration slit proteins and their functions: a scoping review

Frontiers in Nephrology
BackgroundFiltration slit proteins are important for maintaining the integrity of the glomerular filtration barrier. Genetic mutations and environmental factors can disrupt their structure and functions, leading to proteinuria and kidney diseases.
Aolat Adepeju Adepoju, Mubarak Abubakar Muhammad, Mubashir Mayowa Adamson, Shakirudeen Abdulqodri Adewale, Adedeji Tayyib Adekunle, Lekan Sheriff Ojulari, Abdullateef Isiaka Alagbonsi, Abdullateef Isiaka Alagbonsi   +7 more
doaj   +1 more source

Profiling and annotation of human kidney glomerulus proteome [PDF]

, 2013
Zenyui Cui, Yutaka Yoshida, Bo Xu, Ying Zhang, Masaaki Nameta, Sameh Magdeldin, Tomoo Makiguchi, Toshikazu Ikoma, Hidehiko Fujinaka, Eishin Yaoita, Tadashi Yamamoto   +10 more
openalex   +1 more source