BMJ Open Diabetes Research & Care, 2020 IntroductionHyperglucagonemia is a key pathophysiological driver of type 2 diabetes. Although Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for diabetes, it is presently unclear how surgery alters glucagon physiology.
Kleopatra Alexiadou +14 more
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Frontiers in Endocrinology, 2021 Bone tissue is organized at the molecular level to resist fracture with the minimum of bone material. This implies that several modifications of the extracellular matrix, including enzymatic collagen crosslinking, take place.
Aleksandra Mieczkowska +6 more
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What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]
, 2019 Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra +13 more
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Glucagon-like peptide 1 receptor agonists: A new approach to type 2 diabetes management
South African Family Practice, 2013 Despite advances in options for the treatment of type 2 diabetes, optimal glycaemic control is often not achieved. Hypoglycaemia and weight gain that are associated with many antidiabetic medications may interfere with the implementation and long-term ...
Lynn Lambert
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Dietary squid paste supplementation promotes feed intake via brain-gut dynamic response in Chinese soft-shelled turtle Pelodiscus sinensis [PDF]
PeerJ, 2020 Background As the primary source of protein for aquaculture, fishmeal has reached the extremity of sustainable development, our previous studies have proven that rice protein concentrate and squid paste are outstanding protein source and stimulant for ...
Cunxin Sun +5 more
doaj +2 more sources
An Overview of Appetite-Regulatory Peptides in Addiction Processes; From Bench to Bed Side
Frontiers in Neuroscience, 2021 There is a substantial need for new pharmacological treatments of addiction, and appetite-regulatory peptides are implied as possible candidates. Appetite regulation is complex and involves anorexigenic hormones such as glucagon-like peptide-1 (GLP-1 ...
Olesya T. Shevchouk +2 more
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BMC Gastroenterology, 2012 Background Neuropathy is believed to be a common feature of functional and inflammatory intestinal diseases. Vasoactive intestinal peptide (VIP) is an acknowledged neuroprotective agent in peripheral, including enteric, and central neurons.
Voss Ulrikke +3 more
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Proglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat
, 2015 Reports have suggested a link between treatment with glucagon-like peptide 1 (GLP-1) analogs and an increased risk of pancreatitis. Oxyntomodulin, a dual agonist of both GLP-1 and glucagon receptors, is currently being investigated as a potential ...
Akalestou, E +5 more
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Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. [PDF]
, 2019 The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose ...
Chan, Luisa S +16 more
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Radiolabelled peptides for oncological diagnosis [PDF]
, 2012 Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy.
Peter Laverman +3 more
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