Results 61 to 70 of about 42,175 (206)

Intra-islet glucagon-like peptide 1 [PDF]

Journal of Diabetes and its Complications, 2016
Glucagon-like peptide-1 (GLP-1) is originally identified in the gut as an incretin hormone, and it is potent in stimulating insulin secretion in the pancreas. However, increasing evidence suggests that GLP-1 is also produced locally within pancreatic islets.
Genevieve E. Fava, Emily W. Dong, Hongju Wu   +2 more
openaire   +2 more sources

The Role of Gasotransmitters in Gut Peptide Actions

Frontiers in Pharmacology, 2021
Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles ...
Wout Verbeure, Harry van Goor, Hideki Mori, André P. van Beek, Jan Tack, Peter R. van Dijk   +5 more
doaj   +1 more source

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]

, 1994
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Fiedler, Fritz, Lehnert, Peter, Riepl, Rudolf L., Teufel, Johannes   +3 more
core   +1 more source

Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Molecular Metabolism, 2017
Objective: Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose ...
Xuemei Shi, Shaji Chacko, Feng Li, Depei Li, Douglas Burrin, Lawrence Chan, Xinfu Guan   +6 more
doaj   +1 more source

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

Molecules, 2020
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply.
Sandy Theysgeur, Benoit Cudennec, Barbara Deracinois, Claire Perrin, Isabelle Guiller, Anne Lepoudère, Christophe Flahaut, Rozenn Ravallec   +7 more
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function

Frontiers in Endocrinology, 2017
Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades.
Iacopo Gesmundo, Tania Villanova, Dana Banfi, Giacomo Gamba, Riccarda Granata   +4 more
doaj   +1 more source

Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide

Pharmaceutics, 2020
The number of therapeutic peptides for human treatment is growing rapidly. However, their development faces two major issues: the poor yield of large peptides from conventional solid-phase synthesis, and the intrinsically short serum half-life of ...
Mijeong Bak, Junyong Park, Kiyoon Min, Jinhwan Cho, Jihyoun Seong, Young S. Hahn, Giyoong Tae, Inchan Kwon   +7 more
doaj   +1 more source

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver [PDF]

, 2014
LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro
AK Al-Hakim, B Guigas, BL Williamson, C Kellendonk, C Kress, DG Hardie, DR Alessi, E Henriksson, G Rena, G Zhou, HV Lin, J Le Lay, J Luo, J Schaft, JA Vizcaino, JM Lizcano, JW Scott, JY Altarejos, K Clark, K Sakamoto, L Logie, L Ozcan, M Foretz, M Montminy, M Schuler, M Wan, MJ Sanders, MM Mihaylova, MN Berry, N Bardeesy, N Horike, O Goransson, P Tsou, R Dentin, RA Miller, RA Screaton, RJ Shaw, SH Koo, Y Wang, Z Wang   +39 more
core   +5 more sources