Results 11 to 20 of about 222,938 (359)

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]

, 2016
Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I., Elhachmane, M., Gopel, S., Pedersen, MORTEN GRAM   +3 more
core   +1 more source

The entero-insular axis: a journey in the physiopathology of diabetes

Exploration of Medicine, 2020
Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role.
Roberta Malaguarnera, Alessandra Scamporrino, Agnese Filippello, Stefania Di Mauro, Alessandro Minardo, Francesco Purrello, Salvatore Piro   +6 more
doaj   +1 more source

Feeding frequency has diet-dependent effects on plasma hormone concentrations but does not affect oocyte quality in dairy heifers fed fibre- or starch-based diets

Animal, 2008
The post-fertilisation developmental capacity of bovine oocytes recovered by ultrasound guided transvaginal follicular aspiration (ovum pick-up, OPU) is influenced by diet-induced changes in hormone and metabolite concentrations.
J.A. Rooke, A. Ainslie, R.G. Watt, F.M. Alink, T.G. McEvoy, K.D. Sinclair, P.C. Garnsworthy, R. Webb   +7 more
doaj   +1 more source

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]

, 1976
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard, Bollman, Bucher, Child, Eck, Felig, Felig, Field, Fisher, Fisher, Hahn, Holley, Izzo, Leffert, Loud, Madison, Mann, Marchioro, Marchioro, Marchioro, Meyer, Popper, Reaven, Rous, Rubin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Tchobroutsky, Warren, Wembren, Younger   +36 more
core   +1 more source

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia

Frontiers in Endocrinology, 2021
Patients with diabetes mellitus exhibit hyperglucagonemia, or excess glucagon secretion, which may be the underlying cause of the hyperglycemia of diabetes.
Farzad Asadi, Farzad Asadi, Savita Dhanvantari, Savita Dhanvantari, Savita Dhanvantari, Savita Dhanvantari   +5 more
doaj   +1 more source

Glucagon: Physiological and Pharmacological Functions and Pathophysiological Significance in Type 2 Diabetes [PDF]

Endocrinology and Metabolism
Glucagon has many functions, including the promotion of hepatic glucose production, fatty acid oxidation, thermogenesis, energy consumption, lipolysis, and myocardial contraction, as well as the suppression of lipogenesis, appetite, and gastrointestinal ...
Tadahiro Kitamura
doaj   +1 more source

Effect of dipeptidyl peptidase-4 inhibitors on postprandial glucagon level in patients with type 2 diabetes mellitus: A systemic review and meta-analysis

Frontiers in Endocrinology, 2022
AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai, Ruya Zhang, Ye Zhang, Richard David Carr, Yiman Zheng, Swapnil Rajpathak, Linong Ji   +6 more
doaj   +1 more source

The relationship between insulin and glucagon concentrations in non‐diabetic humans

Physiological Reports, 2022
Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship.
Marcello C. Laurenti, Praveer Arora, Chiara Dalla Man, James C. Andrews, Robert A. Rizza, Aleksey Matveyenko, Kent R. Bailey, Claudio Cobelli, Adrian Vella   +8 more
doaj   +1 more source

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality.
Mirjam E. van Albada, Klaus Mohnike, Mark J. Dunne, Indi Banerjee, Stephen F. Betz   +4 more
doaj   +1 more source