Results 21 to 30 of about 114,692 (269)
Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents [PDF]
, 2020 The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations in order to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes in AMPK activation and the cellular energy state in ...
arxiv +1 more source
Frontiers in Pharmacology, 2023 Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, and ...
Kyle D. Medak +11 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Administering more than 10 times the therapeutic dose of insulin is extremely rare in diabetic dogs and is life threatening with hypoglycemia and seizures if not accompanied by appropriate treatment.
Jun-Hyeong Park +7 more
doaj +1 more source
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
PLoS ONE 11(4):e0152446 (2016), 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while the role of $\delta$ cells is less clear.
arxiv +1 more source
Basal Glucose Control in Type 1 Diabetes using Deep Reinforcement Learning: An In Silico Validation [PDF]
IEEE journal of biomedical and health informatics 2020, 2020 People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the ...
arxiv +1 more source
New uses and formulations of glucagon for hypoglycaemia
Drugs in Context, 2019 Hypoglycaemia is the more frequent complication of insulin therapy and the main barrier to tight glycaemic control. Injectable glucagon and oral intake of carbohydrates are the recommended treatments for severe and non-severe hypoglycaemia episodes ...
Pilar I Beato-Víbora +1 more
doaj +1 more source
ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022 The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak +3 more
wiley +1 more source
Nonlinear Model Predictive Control and System Identification for a Dual-hormone Artificial Pancreas [PDF]
arXiv, 2022 In this work, we present a switching nonlinear model predictive control (NMPC) algorithm for a dual-hormone artificial pancreas (AP), and we use maximum likelihood estimation (MLE) to identify model parameters. A dual-hormone AP consists of a continuous glucose monitor (CGM), a control algorithm, an insulin pump, and a glucagon pump. The AP is designed
arxiv
Postprandial dysfunction in fatty liver disease
Physiological Reports, 2023 Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important.
Josephine Grandt +13 more
doaj +1 more source
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1449-1455, December 2022., 2022 Abstract Objectives The extraction of a tooth exacerbates the stress in diabetic patients leading to diabetic complications so the aim was to evaluate the changes in blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction to pay special attention during a routine surgical procedure.
Zana Agani +6 more
wiley +1 more source