Results 81 to 90 of about 214,982 (356)

13C MRS Studies of the Control of Hepatic Glycogen Metabolism at High Magnetic Fields

open access: yesFrontiers in Physics, 2017
Introduction: Glycogen is the primary intracellular storage form of carbohydrates. In contrast to most tissues where stored glycogen can only supply the local tissue with energy, hepatic glycogen is mobilized and released into the blood to maintain ...
Corin O. Miller   +6 more
doaj   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

open access: yesAdvanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen   +13 more
wiley   +1 more source

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle [PDF]

open access: yes, 2013
Peer reviewedPublisher ...
Bestwick, Charles   +6 more
core   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

open access: yesAdvanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang   +13 more
wiley   +1 more source

From classical dualistic antagonism to hormone synergy: potential of overlapping action of glucagon, insulin and GLP-1 for the treatment of diabesity

open access: yesEndocrine Connections
The increasing prevalence of ‘diabesity’, a combination of type 2 diabetes and obesity, poses a significant global health challenge. Unhealthy lifestyle factors, including poor diet, sedentary behaviour, and high stress levels, combined with genetic and ...
Svjatoslavs Kistkins   +8 more
doaj   +1 more source

The glucagon-like Peptide-2 [PDF]

open access: yes, 2011
Multiple peptide hormones produced within the gastrointestinal system act also in the central nervous system and aid in the regulation of energy homeostasis and metabolism. The list of these peptides is progressively increasing and includes glucagon-like
Mule, Flava
core  

Stop-and-go kinetics in amyloid fibrillation [PDF]

open access: yes, 2009
Many human diseases are associated with protein aggregation and fibrillation. Using glucagon as a model system for protein fibrillation we show that fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. Remarkably, even
Christian Beyschau Andersen   +10 more
core   +5 more sources

BRD4 Signaling Maintains the Differentiated State of β Cells

open access: yesAdvanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu   +22 more
wiley   +1 more source

Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome

open access: yesFrontiers in Physiology, 2017
Glucagon, produced by islet α cells, functions to increase blood glucose. Abnormal glucose levels are often seen in cystic fibrosis (CF), a systematic disease caused by mutations of the CF transmembrane conductance regulator (CFTR), and in polycystic ...
Wen Qing Huang   +11 more
doaj   +1 more source

Euglycemic Diabetic Ketoacidosis in Concurrent Very Low-carbohydrate Diet and Sodium-glucose Transporter-2 Inhibitor Use: A Case Report [PDF]

open access: yes, 2020
Introduction: With the incredibly high incidence of Type 2 Diabetes in the current population of emergency department patients, it is critical for clinicians to understand the possible complications of the treatment of this disease.
Ault, Brian   +2 more
core  

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