Results 51 to 60 of about 443,164 (406)

Leukotriene antagonists as first-line or add-on asthma controller therapy [PDF]

, 2011
Most randomized trials of treatment for asthma study highly selected patients under idealized conditions. METHODS: We conducted two parallel, multicenter, pragmatic trials to evaluate the real-world effectiveness of a leukotriene-receptor antagonist ...
Annie Blyth, Daryl Freeman, David Price, Ducharme FM, Edward C.F. Wilson, Elizabeth F. Juniper, Elizabeth V. Hillyer, Erika J. Sims, H. Miranda Mugford, Ian Harvey, Jamie Murdoch, Jon G. Ayres, Juniper EF, Lee Shepstone, Linda Kemp, Malmstrom K, O'Byrne PM, Richard F.T. Gilbert, Santanello NC, Stanley D. Musgrave, Stephanie Wolfe, Temple R, Thomas M   +22 more
core   +1 more source

Efficacy of the exhalation delivery system with fluticasone in patients with chronic rhinosinusitis with nasal polyps whose symptoms recur after sinus surgery

International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 31-41, January 2023., 2023
Abstract Background Sinus surgery removes inflamed tissue, restores airflow, and improves delivery of medication into surgically opened spaces. The exhalation delivery system with fluticasone (EDS‐FLU; XHANCE®) uses a novel delivery system to create closed‐palate, positive‐pressure, bidirectional mechanics that significantly alter the deposition of the
Randall A. Ow, Zachary M. Soler, Raj Sindwani, Donald A. Leopold, Jivianne T. Lee, Ramy A. Mahmoud, Joseph K. Han   +6 more
wiley   +1 more source

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Influence of Implant Surface Topography on Primary Stability in a Standardized Osteoporosis Rabbit Model Study

Journal of Functional Biomaterials, 2015
Evaluating primary stability is important to predict the prognosis of dental implant treatment. Primary stability is decreased in a low bone density site such as osteoporosis.
Hiroshi Oue, Kazuya Doi, Yoshifumi Oki, Yusuke Makihara, Takayasu Kubo, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga   +8 more
doaj   +1 more source

Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders.

Genes and Immunity, 2020
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.
R. Slominski, R. Tuckey, P. Manna, A. Jetten, A. Postlethwaite, C. Raman, A. Slominski   +6 more
semanticscholar   +1 more source

Diagnosis and approach to glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome

Journal of Education, Health and Sport
Introduction and purpose: Primary adrenal insufficiency can result from diseases affecting the adrenal glands, while secondary adrenal insufficiency is caused by suppression of the hypothalamic-pituitary-adrenal axis.
Aleksandra Kiełczewska, Grzegorz Szcześniak, Anna Kiełczewska   +2 more
doaj   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1 [PDF]

arXiv, 2023
Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in
arxiv  

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source