Results 81 to 90 of about 443,164 (406)

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Two‐Year Follow‐Up of a Multidisciplinary Lifestyle Intervention for Rheumatoid Arthritis and Osteoarthritis

Arthritis Care &Research, Accepted Article.
Objective The Plants for Joints intervention (PFJ), including a whole‐food plant‐based diet, exercise, and stress reduction, reduced signs and symptoms of rheumatoid arthritis (RA) or metabolic syndrome‐associated hip or knee osteoarthritis (MSOA) compared to usual care. This study examined outcomes two years later. Methods After two 16‐week randomized
Carlijn A. Wagenaar, Wendy Walrabenstein, Marike van der Leeden, Franktien Turkstra, Martijn Gerritsen, Jos W.R. Twisk, Maarten Boers, Martin van der Esch, Henriët van Middendorp, Peter J.M. Weijs, Dirkjan van Schaardenburg   +10 more
wiley   +1 more source

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics [PDF]

, 2016
The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that regulates numerous physiological processes. Disruptions in the activity of the HPA axis are correlated with many stress-related diseases such as post-traumatic stress disorder (PTSD) and major depressive disorder.
arxiv   +1 more source

GLUCOCORTICOID THERAPY

Medicine, 1976
1. There is a poor relationship between the circulating half-life a glucocorticoid and either its potency or its duration of action. Many actions of a glucocorticoid have unequal durations. The duration of action varies with the dose. 2. The presence of biological activity as a glucocorticoid depends on the presence of a hydroxyl group at carbon number
openaire   +3 more sources

Ageism in Rheumatology: the Healthcare Professional's Perspective

Arthritis Care &Research, Accepted Article.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the healthcare professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact ...
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra, Anne-Margriet Huisman, Ans C.M. Oostveen, Ben A.C. Dijkmans, Chris E.D. de Laet, de Nijs RN, Erik Buskens, George A.W. Bruyn, Johannes W.G. Jacobs, Johannes W.J. Bijlsma, Michel BA, Piet P.M.M. Geusens, Roland F.J. Laan, Ron N.J. de Nijs, Willem F. Lems   +14 more
core   +4 more sources

Glucocorticoid-induced osteoporosis

RMD Open, 2015
Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the first cause in young people. Bone loss and increased rate of fractures occur early after the initiation of corticosteroid therapy, and are then related to ...
K. Briot, C. Roux
semanticscholar   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]

, 2017
BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S, Lynch, Frank J, Munster, Pamela N, Murphy, Tiffany I, Nguyen, Dat P   +4 more
core   +2 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source