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Glucocorticoid Receptor and Adipocyte Biology. [PDF]
Nuclear Receptor Research, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A +2 more
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The Glucocorticoid Receptor in Cardiovascular Health and Disease
Cells, 2019 The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in ...
Bing Liu +3 more
doaj +2 more sources
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
Nature Communications, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
core +4 more sources
Glucocorticoid receptor signaling in the brain and its involvement in cognitive function [PDF]
Neural Regeneration ResearchThe hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su +5 more
doaj +2 more sources
Glucocorticoid Receptor Maintains Vasopressin Responses in Kidney Collecting Duct Cells
Frontiers in Physiology, 2022 Water permeability of the kidney collecting ducts is regulated in part by the amount of the molecular water channel protein aquaporin-2 (AQP2), whose expression, in turn, is regulated by the pituitary peptide hormone vasopressin.
Hsiu-Hui Yang +5 more
doaj +1 more source
Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
Nature Communications, 2021 Endothelial cells play a key role in the regulation of disease. Defective regulation of endothelial cell homeostasis may cause mesenchymal activation of other endothelial cells or neighboring cell types, and in both cases contributes to organ fibrosis ...
S. Srivastava +5 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +1 more source
B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
doaj +1 more source
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]
Journal of Integrative Neuroscience, 2020 Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
doaj +1 more source
Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour
Cells, 2023 Background. The dual role of GCs has been observed in breast cancer; however, due to many concomitant factors, GR action in cancer biology is still ambiguous. In this study, we aimed to unravel the context-dependent action of GR in breast cancer. Methods.
Henriett Butz +11 more
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