Results 211 to 220 of about 199,077 (362)

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

The Alkaloid Caulerpin Exhibits Potent and Selective Anti-Inflammatory Activity Through Interaction with the Glucocorticoid Receptor. [PDF]

Mar Drugs
Dos Santos JSP, Silva DKC, da Silva Oliveira V, Junior SSS, Dos Santos Rodrigues E, de Souza CVC, Martinez ST, Santos-Filho OA, Meira CS, Soares MBP.   +9 more
europepmc   +1 more source

The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein.

, 1987
Marc G. Denis, A C Wikström, Jan Gustafsson   +2 more
openalex   +1 more source

Biochemical and Molecular Characterization of the Glucocorticoid Receptor of Lymphosarcoma P1798 Variants [PDF]

, 1988
Karen L. Lucas, Karen W. Barbour, Paul R. Housley, E. Aubrey Thompson   +3 more
openalex   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

<i>In vitro</i> to <i>in vivo</i> evidence for chemical disruption of glucocorticoid receptor signaling. [PDF]

Toxicol Rep
Morris MT, Pascoe JL, Busada JT.
europepmc   +1 more source

Glucocorticoids increase cholecystokinin receptors and amylase secretion in pancreatic acinar AR42J cells.

, 1986
Craig D. Logsdon
openalex   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. [PDF]

Sci Adv
Prabakaran AD, Montecino-Morales F, McFarland K, Govindarajan T, Durumutla HB, Latimer H, Akinborewa O, Villa C, Millay DP, Quattrocelli M.   +9 more
europepmc   +1 more source

Kinetic and thermodynamic evidence of a molybdate interaction with glucocorticoid receptor in calf thymus [PDF]

, 1983
Paolo P. Cardo, Maurizio GAMBETTI, Bruno VIGNALE, M.C. Divano   +3 more
openalex   +1 more source