Results 221 to 230 of about 219,440 (263)

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling

Tamta AK, Shivanaiah B, Prabhashankar AB, Ningaraju S, Subhadarshini S, Sharma AN, Jayaprakasan HM, E R MK, Bhuyar A, Sunil D, Shrama A, Nagesh D, Munjal A, Raghu S, Madhuri MB, Rajesh D, Ramasubbu V, Sarikhani M, Tandon H, Desingu PA, Diwakar L, Nath U, Nair D, Singh A, Sowdhamini R, Srinivasan N, Mostoslavsky R, Asirvatham-Jeyaraj N, Sundaresan NR.   +28 more
europepmc   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis. [PDF]

Adv Sci (Weinh)
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J.   +10 more
europepmc   +1 more source

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort. [PDF]

Sci Rep
Sombetzki C, Palmowski L, Ziehe D, Nowak H, Rahmel T, Ehrentraut SF, Thon P, Orlowski J, Bergmann L, Adamzik M, Koos B, Rump K, SepsisDataNet.NRW research group.   +12 more
europepmc   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis. [PDF]

J Clin Invest
Durumutla HB, Haller A, Noble G, Prabakaran AD, McFarland K, Latimer H, Rajput A, Akinborewa O, Namjou-Khales B, Hui DY, Quattrocelli M.   +10 more
europepmc   +1 more source

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 900-911, April 2025.
Central illustration. Abbreviations: ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNi, angiotensin‐receptor‐neprilysin inhibitor; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; CV, cardiovascular; EF, ejection fraction; eGFR, estimated glomerular ...
Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese   +12 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

TENT5C functions as a corepressor in the ligand-bound glucocorticoid receptor and estrogen receptor α complexes. [PDF]

FEBS J
Li Y, Perera L, He RS, Baptissart M, Petrovich RM, Morgan M.   +5 more
europepmc   +1 more source