Results 251 to 260 of about 2,551,103 (363)

Primary structure and expression of a functional human glucocorticoid receptor cDNA

Nature, 1985
S. Hollenberg, S. Hollenberg, C. Weinberger, E. Ong, G. Cerelli, A. Oro, R. Lebo, E. Thompson, M. Rosenfeld, R. Evans   +9 more
semanticscholar   +1 more source

Asymmetric Synthesis and Biological Evaluation of 1,3‐ and 1,4‐Disubstituted Isoquinoline‐Containing Lipoxin A4 Analogues

Chemistry – A European Journal, EarlyView.
(1R)‐ and (1S)‐Epimers of novel isoquinoline‐derived SPMs were prepared, with a Pd‐catalyzed Heck reaction and a Ru(II)‐catalyzed asymmetric transfer hydrogenation as the key synthetic steps. Biological assessment demonstrated that several analogues significantly attenuate lipopolysaccharide‐induced NF‐κB activation and downstream pro‐inflammatory ...
Denise Moran, Monica de Gaetano, Braden Millar, Catherine Godson, Patrick J. Guiry   +4 more
wiley   +1 more source

The Alkaloid Caulerpin Exhibits Potent and Selective Anti-Inflammatory Activity Through Interaction with the Glucocorticoid Receptor. [PDF]

Mar Drugs
Dos Santos JSP, Silva DKC, da Silva Oliveira V, Junior SSS, Dos Santos Rodrigues E, de Souza CVC, Martinez ST, Santos-Filho OA, Meira CS, Soares MBP.   +9 more
europepmc   +1 more source

Comparison of glucocorticoid-receptor binding kinetics with predictions from a biomolecular model.

, 1980
Joanne M. Yeakley, Karundevi Balasubramanian, Robert W. Harrison   +2 more
openalex   +1 more source

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

<i>In vitro</i> to <i>in vivo</i> evidence for chemical disruption of glucocorticoid receptor signaling. [PDF]

Toxicol Rep
Morris MT, Pascoe JL, Busada JT.
europepmc   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. [PDF]

Sci Adv
Prabakaran AD, Montecino-Morales F, McFarland K, Govindarajan T, Durumutla HB, Latimer H, Akinborewa O, Villa C, Millay DP, Quattrocelli M.   +9 more
europepmc   +1 more source

Synergistic regulation of pulmonary beta-adrenergic receptors by glucocorticoids and interleukin-1.

, 1988
L Stern, George Kunos
openalex   +1 more source