Results 271 to 280 of about 142,613 (313)
Some of the next articles are maybe not open access.
The structure of glucocorticoid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1993The glucocorticoid receptor of mouse thymic lymphoma cells was investigated. The receptor-hormone complex in cytosolic extracts has a Stokes' radius of 82 A and Mw approximately 330 kDa. In the presence of salt at high concentrations, however, the receptor-complex has a Stokes' radius of 60 A and Mw approximately 120 kDa.
openaire +2 more sources
Glucocorticoid Receptors In the Brain
Hospital Practice, 1988The ability to downregulate the stress response is essential to good health. We still have much to learn about the biochemical bases of glucocorticoid effects on brain function—but it is now clear that the interaction between hormones and neurons provides a pathway by which thoughts and emotions can influence hormone secretion and hormones can ...
openaire +2 more sources
Glucocorticoid Receptors and Resistance to Glucocorticoids in Hematologic Malignancies
Leukemia & Lymphoma, 1994Glucocorticoids are highly effective in inducing the cytolysis of cells of lymphocytic origin. This property has resulted in their incorporation into chemotherapy regimens used in the treatment of hematologic malignancies. Studies at the molecular and cellular levels have demonstrated that the hormone-induced cytolytic response is mediated through a ...
P A, Moalli, S T, Rosen
openaire +2 more sources
Genetics of glucocorticoid receptors
Molecular and Cellular Endocrinology, 1986The lymphocytolytic effect of glucocorticoids has been used for isolating receptor mutants. They fall into several groups with defects either in the hormone binding domain or the DNA binding domain or with part of the receptor polypeptide missing. These truncated receptors have increased binding affinity for general DNA and are synthesized from 5 ...
openaire +2 more sources
Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry, 2008This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
openaire +2 more sources
CORTICOSTEROIDS | Glucocorticoid Receptors
2006Corticosteroids bind to and activate a cytoplasmic glucocorticoid receptor (GR) which exists as several isoforms derived from a single gene product by alternative splicing. The activated glucocorticoid receptor translocates into the nucleus and binds to specific response elements in the promoter regions of anti-inflammatory genes such as lipocortin-1 ...
Adcock I. M. +3 more
openaire +3 more sources
Localization of the Glucocorticoid Receptor in Rat Brain Mitochondria
Archives of Biochemistry and Biophysics, 2001 The distribution of glucocorticoid receptor in subcellular fractions of brain cortex and hippocampus, two regions rich in glucocorticoid receptor, has revealed its presence in nuclei, cytosol, mitochondria, synaptosomes, and synaptosomal mitochondria ...
Paraskevi Moutsatsou +2 more
exaly +1 more source
Interaction of glucocorticoid analogues with the human glucocorticoid receptor
The Journal of Steroid Biochemistry and Molecular Biology, 1992Transient co-transfection of receptor cDNA and suitable reporter genes was used to study human glucocorticoid receptor (hGR) function in a neutral mammalian cell background. A variety of natural and synthetic steroids were analyzed for their ability to activate gene expression through the hGR and to bind to extracts of cells expressing the hGR cDNA ...
T S, Berger +3 more
openaire +2 more sources
Chaperoning of Glucocorticoid Receptors
2005A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradle-to-grave' system for regulating the steroid binding, trafficking and turnover of the glucocorticoid receptor (GR). In an ATP-dependent process where hsp70 and hsp90 act as essential chaperones and Hop, hsp40, and p23 act as nonessential co-chaperones, the machinery assembles ...
W B, Pratt +3 more
openaire +2 more sources
Glucocorticoid receptor regulation
Life Sciences, 1985Glucocorticoids, like other classes of steroid hormones, must bind to cellular receptors in order to exert their effects. Because of this central role in mediating hormone action, it is important to elucidate those factors that control receptor content.
openaire +2 more sources