Results 281 to 290 of about 199,077 (362)

Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate

JEADV Clinical Practice, EarlyView.
We present a case of a 31‐year‐old female with alopecia universalis, psoriasis vulgaris, and psoriatic arthritis, who showed poor response to prior treatments. Following the initiation of a combination therapy with tofacitinib and methotrexate, significant improvements in joint pain and hair regrowth were observed.
Jan Nicolai Wagner, Matthias Augustin, Caroline Gewiss, Carolin Grote, Nesrine Ben‐Anaya   +4 more
wiley   +1 more source

Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats. [PDF]

PNAS Nexus
Jaumotte JD, El Khoury N, Min CK, Wang J, Madigan C, Jano A, Russo Kobylski RJ, Solt LA, Dhavan RS, Short KL, Lei T, Chandran U, Cole TJ, Monaghan-Nichols AP, Sampath V, Houtman R, Nettles KW, DeFranco DB.   +17 more
europepmc   +1 more source

Deletion of NFIA Leads to Activation of S100A7 and Inflammatory Response‐Induced Apoptosis of Keratinocytes in Oral Lichen Planus Progression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT S100 calcium‐binding protein A7 (S100A7) has been implicated in psoriasis and other inflammatory diseases. However, the function of S100A7 in oral lichen planus (OLP), a chronic inflammatory disease, remains unclear. OLP was induced in mice by transplanting human OLP lesions into the backs of thymus‐free mice, and an in vitro cell model was ...
Maimaiti Tudi, Zumulaiti Aierken, Maihebubaimu Tuerxun, Maimaitituxun Tuerdi   +3 more
wiley   +1 more source

Characteristics of eligible patients with knee osteoarthritis accepting versus declining participation in a randomised trial investigating the effect of weight loss versus knee arthroplasty to explore generalisability: A cross‐sectional study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Background The INtensive diet versus Knee Arthroplasty (INKA) trial is a randomised trial assessing weight loss as an alternative to knee arthroplasty (KA) in obese patients with severe knee osteoarthritis (OA) awaiting KA (NCT05172843). The external validity of the INKA trial may be hampered if the patients who participate differ from those ...
Saber Muthanna Aljuboori, Robin Christensen, Marius Henriksen, Henning Bliddal, Anders Troelsen, Mikael Boesen, Asbjørn Seenithamby Poulsen, Camilla Toft Nielsen, Kristine Ifigenia Bunyoz, Søren Overgaard   +9 more
wiley   +1 more source

miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA. [PDF]

Poult Sci
Zhao M, Chen L, Zhao Y, Liu J, Chen H, Zhao R.   +5 more
europepmc   +1 more source

Post‐operative joint stiffness after Bereiter trochleoplasty does not affect 2‐year improvement in patient‐reported outcomes. A prospective cohort study of 374 Bereiter trochleoplasties

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Bereiter trochleoplasty (TP) is a well‐described procedure to address trochlear dysplasia (TD). Post‐operative joint stiffness with reduced range of motion (ROM) is a common complication usually requiring arthroscopically assisted manipulation (AAM) with the removal of adhesions and scar tissue. Inferior clinical outcomes after TP have
Christian Dippmann, Christos Soleas, Anke Simone Rechter, Volkert Siersma, Kristoffer Weisskirchner Barfod, Peter Lavard   +5 more
wiley   +1 more source

Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome. [PDF]

Ital J Pediatr
Liang YH, Liang C, Cheng J, Peng Q, Zeng P, Guan F.   +5 more
europepmc   +1 more source

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders. [PDF]

Pharmacol Rep
Göver T, Slezak M.
europepmc   +1 more source

Bovine Milk Extracellular Vesicles as a Preventive Treatment for Bone Dysfunction and Metabolic Alterations in Obese Mice Fed a High‐Refined Carbohydrate Diet

Molecular Nutrition &Food Research, EarlyView.
Obesity induction through a high‐refined carbohydrate (HC) diet in BALB/c mice led to increased bone resorption and bone loss in the femur and maxilla. This diet also resulted in increased adiposity, glucose and lipid levels, and insulin resistance. Treatment with bovine milk extracellular vesicles (MEVs) in HC diet‐fed mice demonstrated reduced bone ...
Francine R. F. Silva, Joyce E. Heredia, Onno J. Arntz, Breno R. Barrioni, Mauro M. Teixeira, Tarcília A. Silva, Fons A. J. van de Loo, Soraia Macari, Adaliene V. M. Ferreira, Marina C. Oliveira   +9 more
wiley   +1 more source