Results 21 to 30 of about 2,551,103 (363)
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]
, 2009 The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky +26 more
core +2 more sources
Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling
Stem Cell Research & Therapy, 2021 Background Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to and from the bone marrow (BM) is a
Wenting Gao +6 more
doaj +1 more source
Molecular Metabolism, 2021 Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute ...
Rachel M.B. Bell +18 more
doaj +1 more source
A thyroid hormone receptor-dependent glucocorticoid induction. [PDF]
, 1994 Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a thyroid ...
Leers, Joerg +3 more
core +1 more source
Translational Psychiatry, 2018 Gut microbiota has an important role in the immune system, metabolism, and digestion, and has a significant effect on the nervous system. Recent studies have revealed that abnormal gut microbiota induces abnormal behaviors, which may be associated with ...
Yuanyuan Luo +13 more
semanticscholar +1 more source
Интегративная физиология, 2021 Glucocorticoids (GC) are crucial regulators of homeostasis and function. Despite its negative side effects, glucocorticoid therapy in neonates is widely used antenatally for accelerating fetal lung maturation in cases of preterm birth.
Дмитрий Александрович Ланшаков +4 more
doaj +1 more source
Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]
, 2018 Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse +5 more
core +3 more sources
F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Journal of Xenobiotics, 2022 Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj +1 more source