Results 21 to 30 of about 2,524,396 (364)
Translational Psychiatry, 2018 Gut microbiota has an important role in the immune system, metabolism, and digestion, and has a significant effect on the nervous system. Recent studies have revealed that abnormal gut microbiota induces abnormal behaviors, which may be associated with ...
Yuanyuan Luo +13 more
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Интегративная физиология, 2021 Glucocorticoids (GC) are crucial regulators of homeostasis and function. Despite its negative side effects, glucocorticoid therapy in neonates is widely used antenatally for accelerating fetal lung maturation in cases of preterm birth.
Дмитрий Александрович Ланшаков +4 more
doaj +1 more source
Stress and glucocorticoid receptor regulation of mitochondrial gene expression.
Journal of Molecular Endocrinology, 2019 Glucocorticoids have long been recognized for their role in regulating the availability of energetic resources, particularly during stress. Furthermore, bidirectional connections between glucocorticoids and the physiology and function of mitochondria ...
H. Lapp, A. Bartlett, R. Hunter
semanticscholar +1 more source
F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Journal of Xenobiotics, 2022 Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj +1 more source
Glucocorticoid Receptor–Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses [PDF]
Endocrinology, 2019 Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals. High expression of MRs and GRs occurs in the same cells in the limbic system, the primary site of glucocorticoid action on cognition, behavior, and mood; however, modes of ...
Caroline A Rivers +5 more
openaire +4 more sources
Glucocorticoid receptor signalling activates YAP in breast cancer
Nature Communications, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
G. Sorrentino +12 more
semanticscholar +1 more source
F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Glucocorticoid Receptor and Adipocyte Biology
Nuclear Receptor Research, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Rebecca A. Lee +2 more
semanticscholar +1 more source
Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells
Cancer Cell International, 2007 Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad +3 more
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