Results 291 to 300 of about 199,077 (362)

All-in-one CRISPR/Cas-engineered glucocorticoid-receptor knock-out EBV-gp350-CAR knock-in T cells are potent and resistant to dexamethasone. [PDF]

Exp Hematol Oncol
Kaeuferle T, Zwermann M, Stoll N, Ferrada-Ernst P, Jablonowski L, Zeidler R, Willier S, Stenger D, Yassin A, Stripecke R, Feuchtinger T.   +10 more
europepmc   +1 more source

Mycophenolate Facilitates Improvement in Outcome Measures in Treatment Resistant Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a potentially disabling autoimmune neuropathy. Approximately 20% of patients are refractory to first‐line treatments necessitating second‐line options with limited evidence and potential adverse effects.
Shamim Miah, Nicole Japzon, Amar Elsaddig, Shiwen Koay, Laura Compton, Michael P. Lunn, Aisling S. Carr   +6 more
wiley   +1 more source

The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism. [PDF]

Endocr J
Okuno Y, Fukuhara A, Shimomura I.
europepmc   +1 more source

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Pharmacokinetics/pharmacodynamics of glucocorticoids: modeling the glucocorticoid receptor dynamics and dose/response of commonly prescribed glucocorticoids. [PDF]

ADMET DMPK
Levitt DG.
europepmc   +1 more source

Quantitative Muscle Ultrasound: A Non‐Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Quantitative muscle ultrasound (QMUS) shows promise as a non‐invasive biomarker for monitoring functional status in Duchenne muscular dystrophy (DMD). We evaluated the correlation between QMUS in various muscles and functional capacity assessments.
Yu Jin Im, Yumi Choe, Jiwon Lee, Jeehun Lee, Jong Geol Do, Jeong‐Yi Kwon   +5 more
wiley   +1 more source

Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors. [PDF]

Cancer Res
Welte T, Vuttaradhi VK, Khlebus EY, Brodsky A, Flores Legarreta A, Celestino J, Powell RT, Stephan CC, Nguyen N, Li J, Takamatsu S, Calzoncinth K, Sood AK, Gershenson DM, Futreal PA, Lawson B, Hillman RT.   +16 more
europepmc   +1 more source

Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone. [PDF]

Front Pharmacol
Bhandari S, Kyrrestad I, Simón-Santamaría J, Li R, Szafranska KJ, Dumitriu G, Sánchez Romano J, Smedsrød B, Sørensen KK.   +8 more
europepmc   +1 more source

Novel selective glucocorticoid receptor modulator GRM-01 demonstrates dissociation of anti-inflammatory effects from adverse effects on glucose and bone metabolism. [PDF]

Front Pharmacol
Jakob F, Hennen S, Gautrois M, Khalil F, Lockhart A.   +4 more
europepmc   +1 more source