Results 31 to 40 of about 2,524,396 (364)

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
doaj   +1 more source

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

Cell Reports, 2018
Summary: Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing’s syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies.
Matthew A. Quinn, Xiaojiang Xu, Melania Ronfani, John A. Cidlowski   +3 more
doaj   +1 more source

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts

Biomolecules, 2023
Over several decades, excess glucocorticoids (GCs) of endogenous or exogenous origin have been recognized to significantly inhibit collagen synthesis and accelerate skin aging. However, little is known regarding their molecular mechanisms.
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research
The hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su, Taiqi Huang, Meiyu Zhang, Yanyu Zhang, Yan Zeng, Xingxing Chen   +5 more
doaj   +1 more source

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Nature Reviews Endocrinology, 2022
Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and immunosuppressive therapeutics in the 1940s and their continued use and development have successfully revolutionized the management of acute and chronic inflammatory ...
Jiaxue Li, C. Cummins
semanticscholar   +1 more source

NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells

Nature Genetics, 2015
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis.
S. Paugh, E. Bonten, D. Savic, Laura B. Ramsey, William E Thierfelder, Prajwal Gurung, R. Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R. Coss, Lucas T. Laudermilk, J. Panetta, J. McCorkle, Yiping Fan, K R Crews, Gabriele Stocco, M. Wilkinson, Antonio M. Ferreira, Cheng Cheng, Wenjian Yang, Seth E. Karol, Christian A. Fernandez, B. Diouf, Colton A. Smith, J. K. Hicks, Alessandra Zanut, Audrey Giordanengo, Dan Crona, Joy J Bianchi, Linda Holmfeldt, C. Mullighan, M. D. den Boer, Rob Pieters, S. Jeha, Thomas L. Dunwell, Farida Latif, D. Bhojwani, William L. Carroll, Ching-Hon Pui, R. M. Myers, R. K. Guy, T. Kanneganti, M. Relling, William E. Evans   +44 more
semanticscholar   +1 more source

Insight into glucocorticoid receptor signalling through interactome model analysis. [PDF]

PLoS Computational Biology, 2017
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high
Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos   +5 more
doaj   +1 more source

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source

The glucocorticoid receptor resource [PDF]

Nucleic Acids Research, 1996
The glucocorticoid receptor resource focuses on the structure-function relationships of the glucocorticoid receptor. As well as links to sequence and bibliographic databases via the World Wide Web, the database contains sequence comparisons of receptors from different species and source information for glucocorticoid receptor clones, probes, cell lines
M, Danielsen, E, Martinez
openaire   +2 more sources

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae.

PLoS Genetics, 2020
In the last decades in vitro studies highlighted the potential for crosstalk between Hypoxia-Inducible Factor-(HIF) and glucocorticoid-(GC) signalling pathways. However, how this interplay precisely occurs in vivo is still debated. Here, we use zebrafish
Davide Marchi, Kirankumar Santhakumar, Kirankumar Santhakumar, Eleanor Markham, Nan Li, Karl-Heinz Storbeck, Nils Krone, Vincent T Cunliffe, Fredericus J M van Eeden   +8 more
doaj   +1 more source