Results 31 to 40 of about 199,077 (362)

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. [PDF]

, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Chen, Tzu-Chieh, Ching, Cecilia, Foo, Fritz, Kuo, Taiyi, McQueen, Allison, Wang, Jen-Chywan, Yan, Stephanie   +6 more
core   +1 more source

Regulation of CYP3A genes by glucocorticoids in human lung cells [v2; ref status: indexed, http://f1000r.es/1z6]

F1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly   +5 more
doaj   +1 more source

A general introduction to glucocorticoid biology [PDF]

, 2019
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor ...
Libert, Claude, Souffriau, Jolien, Timmermans, Steven   +2 more
core   +1 more source

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells

Cancer Cell International, 2007
Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad, Johnson Betty H, Garza Anna S, Miller Aaron L   +3 more
doaj   +1 more source

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts

Biomolecules, 2023
Over several decades, excess glucocorticoids (GCs) of endogenous or exogenous origin have been recognized to significantly inhibit collagen synthesis and accelerate skin aging. However, little is known regarding their molecular mechanisms.
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists [PDF]

, 2016
Glucocorticoids are steroid hormones widely used to control many inflammatory conditions. These effects are primarily attributed to glucocorticoid receptor transrepressional activities but with concomitant receptor transactivation associated with ...
Almawi, Anna-Maria G. Psarra, Bamberger, Barnes, Baschant, Bledsoe, Borski, Bradford, Buttgereit, Cho, Cidlowski, Das, De Bosscher, Degawa-Yamauchi, Demetra Georgatza, Deng, Dezitter, Dostert, Du, Evans, Gené, Goppelt-Struebe, Gruver-Yates, Harder, He, Hoijman, Hyam, Joh, Joh, Joseph M. Hayes, Kalliope K. Papadopoulou, Kassel, Kim, Kleiman, Kumar, Lee, Lewis-Tuffin, Li, Liberman, Liu, Lotem, López-Royuela, Ma, Mahmoud, Maria Ch. Charalambous, Melarangi, Murphy, Oakley, Oppong, Paraskevi Kylindri, Psarra, Psarra, Psarra, Psarra, Psarra, Pufall, Ramamoorthy, Refojo, Rieger, Rose, Ryu, Salomons, Sapolsky, Schmidt, Sherman, Shimojo, Sionov, Suino-Powell, Sundahl, Tong, Tong, Vandevyver, Vyron A. Gorgogietas, Wang, Yang, Yang, Zaman   +76 more
core   +1 more source

B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity

Neurobiology of Stress, 2023
Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett, Guia Guffanti, Richard G. Hunter   +2 more
doaj  

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]

, 2009
The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky, Bolton, De Bosscher, De Bosscher, Dervan, Gigu  re, Heck, Hermoso, Hsu, K. A. Muzikar, Kielkopf, Lampson, Lee, Li, McKay, N. G. Nickols, P. B. Dervan, Pratt, Reichardt, Ren, Spencer, Stockwell, Trauger, Wang, White, Wu, Young   +26 more
core   +2 more sources

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
doaj   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source