Results 31 to 40 of about 2,425,230 (388)

Glucocorticoid receptor signalling activates YAP in breast cancer

Nature Communications, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
G. Sorrentino, N. Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, C. Marotta, C. Neri, E. Cappuzzello, M. Forcato, A. Rosato, M. Mano, S. Bicciato, G. Del Sal   +12 more
semanticscholar   +1 more source

Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells

Cancer Cell International, 2007
Background Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subsequent alteration of a complex ...
Thompson E Brad, Johnson Betty H, Garza Anna S, Miller Aaron L   +3 more
doaj   +1 more source

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

Efficacy of the exhalation delivery system with fluticasone in patients with chronic rhinosinusitis with nasal polyps whose symptoms recur after sinus surgery

International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 31-41, January 2023., 2023
Abstract Background Sinus surgery removes inflamed tissue, restores airflow, and improves delivery of medication into surgically opened spaces. The exhalation delivery system with fluticasone (EDS‐FLU; XHANCE®) uses a novel delivery system to create closed‐palate, positive‐pressure, bidirectional mechanics that significantly alter the deposition of the
Randall A. Ow, Zachary M. Soler, Raj Sindwani, Donald A. Leopold, Jivianne T. Lee, Ramy A. Mahmoud, Joseph K. Han   +6 more
wiley   +1 more source

Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts

Biomolecules, 2023
Over several decades, excess glucocorticoids (GCs) of endogenous or exogenous origin have been recognized to significantly inhibit collagen synthesis and accelerate skin aging. However, little is known regarding their molecular mechanisms.
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park   +4 more
doaj   +1 more source

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases

Microbiology and Molecular Reviews, 2016
SUMMARY Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for inflammatory and autoimmune diseases. However, their use is often hampered by the onset of adverse effects or resistance.
I. Petta, L. Dejager, M. Ballegeer, S. Lievens, J. Tavernier, K. De Bosscher, C. Libert   +6 more
semanticscholar   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity

Neurobiology of Stress, 2023
Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett, Guia Guffanti, Richard G. Hunter   +2 more
doaj  

An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature

BMC Medical Genetics, 2018
Background Glucocorticoid resistance is a rare, sporadic or familial condition caused by mutation of the gene encoding the glucocorticoid receptor (GR).
Ágnes Molnár, Attila Patócs, István Likó, Gábor Nyírő, Károly Rácz, Miklós Tóth, Beatrix Sármán   +6 more
doaj   +1 more source

The glucocorticoid receptor: cause of or cure for obesity?

American Journal of Physiology. Endocrinology and Metabolism, 2016
Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting lipolysis with acute treatment but lipogenesis with chronic exposure.
K. John, J. Marino, E. R. Sánchez, T. Hinds   +3 more
semanticscholar   +1 more source