Results 51 to 60 of about 2,425,230 (388)
Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain [PDF]
arXiv, 2022 Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), which first appear in cartilaginous fish, such as sharks.
arxiv
Targeting the glucocorticoid receptor in breast and prostate cancers
Science Translational Medicine, 2015 The glucocorticoid receptor has a context-dependent role in breast and prostate cancers and may serve as a therapeutic target. Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers.
Jacob Kach, S. Conzen, R. Szmulewitz
semanticscholar +1 more source
Frontiers in Endocrinology, 2020 Cushing's disease is characterized by excessive adrenocorticotropin hormone (ACTH) secretion caused by a corticotroph tumor of the pituitary gland, leading to hypercortisolism and increased morbidity and mortality. The molecular causes of the disease are
Denis Ciato, Adriana Albani
doaj +1 more source
Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain [PDF]
arXiv, 2021 Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by ...
arxiv
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
Proceedings of the National Academy of Sciences of the United States of America, 2012 We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies.
Sheldon Cohen +6 more
semanticscholar +1 more source
Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
Nature Communications, 2016 To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory ...
Stefanie Schöne +10 more
doaj +1 more source
PLoS Genetics, 2020 In the last decades in vitro studies highlighted the potential for crosstalk between Hypoxia-Inducible Factor-(HIF) and glucocorticoid-(GC) signalling pathways. However, how this interplay precisely occurs in vivo is still debated. Here, we use zebrafish
Davide Marchi +8 more
doaj +1 more source
Molecules, 2020 Ciclesonide is an FDA-approved glucocorticoid used to treat asthma and allergic rhinitis. However, whether it has anticancer and anti-cancer stem cell (CSC) effects is unknown.
Su-Lim Kim +3 more
doaj +1 more source
Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. [PDF]
PLoS ONE, 2014 Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating glucocorticoid receptors and binding to glucocorticoid response elements.
Qin Xue +3 more
doaj +1 more source
Function changing mutations in glucocorticoid receptor evolution correlate with their relevance to mode coupling [PDF]
, 2015 Nonlinear effects in protein dynamics are expected to play role in function, particularly of allosteric nature, by facilitating energy transfer between vibrational modes. A recently proposed method focusing on the non-Gaussian shape of the population near equilibrium projects this information onto real space in order to identify the aminoacids relevant
arxiv +1 more source