Results 1 to 10 of about 164,711 (356)
Hippocampal glucocorticoid receptors modulate status epilepticus severity [PDF]
Neurobiology of Disease, 2023 Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population ...
Kimberly L. Kraus +7 more
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Cocaine disrupts action flexibility via glucocorticoid receptors [PDF]
iScienceSummary: Many addictive drugs increase stress hormone levels. They also alter the propensity of organisms to prospectively select actions based on long-term consequences.
Michelle K. Sequeira +4 more
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Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment [PDF]
Upsala Journal of Medical Sciences, 2020 Background: Prenatal depression is common, with an estimate that up to one in five pregnant women suffers from depressive symptoms. Maternal depression is associated with poor pregnancy outcomes such as preterm birth and low birth-weight.
Åsa Edvinsson +6 more
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False Opposing Fear Memories Are Produced as a Function of the Hippocampal Sector Where Glucocorticoid Receptors Are Activated [PDF]
Frontiers in Behavioral Neuroscience, 2020 Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However,
Nadia Kaouane +8 more
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Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Nature Reviews Molecular Cell Biology, 2017 Matthew T Knuesel +2 more
exaly +3 more sources
PLoS ONE, 2022 Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim +4 more
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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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Frontiers in Psychiatry, 2022 IntroductionAbnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients ...
José Manuel López-Villatoro +16 more
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PLoS ONE, 2020 Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone
John R Pooley +9 more
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Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
Nature Communications, 2021 Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud +13 more
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