Results 81 to 90 of about 164,711 (356)

Early life stress-induced alterations in rat brain structures measured with high resolution MRI. [PDF]

PLoS ONE, 2017
Adverse experiences early in life impair cognitive function both in rodents and humans. In humans this increases the vulnerability to develop mental illnesses while in the rodent brain early life stress (ELS) abnormalities are associated with changes in ...
R Angela Sarabdjitsingh, Manila Loi, Marian Joëls, Rick M Dijkhuizen, Annette van der Toorn   +4 more
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Regulation of triglyceride metabolism by glucocorticoid receptor

Cell & Bioscience, 2012
Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis.
Wang Jen-Chywan, Gray Nora E, Kuo Taiyi, Harris Charles A   +3 more
doaj   +1 more source

Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR

Cell Death and Disease, 2023
The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the stress-inducing level of glucocorticoid triggers mitochondrial dysfunction including defective mitophagy by ...
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han   +7 more
doaj   +1 more source

Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]

, 2012
This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J., Kreutter, M., LaCourt, M., Mantsch, John R., Stroh, G., Vaughn, Linda K., Vranjkovic, Oliver   +6 more
core   +2 more sources

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, EarlyView.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

Cell Reports, 2019
Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid ...
Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell   +4 more
doaj   +1 more source

The hepatoadrenal syndrome: A common yet unrecognized clinical condition [PDF]

, 2005
Objective: Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-
Acton, Ali, Annane, Annane, Baranova, Beishuizen, Borkowski, Calco, Cicognani, Cooper, Darlington, Davies, de la Llera-Moya, Dimopoulou, Eisenberg, Ettinger, Gordon, Hamrahian, Harry, Hinshaw, Jaattela, Kilger, Liu, Liu, Liu, Liu, Loriaux, Marik, Marik, Marik, Marik, Marik, McDonald, Melby, Miyata, Molijn, Molijn, Mookerjee, Paul E. Marik, Rasaratnam, Rivers, Scammell, Singh, Sun, Thomas E. Starzl, Timothy Gayowski, van der Voort, van Leeuwen, Vishnyakova, Yaguchi, Yokoyama, Yokoyama   +51 more
core   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source