Results 111 to 120 of about 185,707 (269)

Growth Hormone Increases Bone Toughness and Decreases Muscle Inflammation in Glucocorticoid-Treated Mdx Mice, Model of Duchenne Muscular Dystrophy [PDF]

, 2019
Sung-Hee Yoon, Marc D. Grynpas, Jane Mitchell   +2 more
openalex   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Glucocorticoids in rheumatology

Indian Journal of Rheumatology, 2022
Shrikant Wagh
doaj   +1 more source

Baseline glucocorticoids alone do not predict reproductive success across years, but in interaction with enzymatic antioxidants

Ecology and Evolution
Glucocorticoids are known to adjust organismal functions, such as metabolism, in response to environmental conditions. Therefore, these hormones are thought to play a key role in regulating the metabolically demanding aspects of reproduction, especially ...
Lucia Mentesana, Stefania Casagrande, Michaela Hau   +2 more
doaj   +1 more source

Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest

, 2020
Reggie Hui‐Chao Lee, Mychal S. Grames, Celeste Yin‐Chieh Wu, Chih-Feng Lien, Alexandre Couto e Silva, HarLee E. Possoit, Garrett A. Clemons, Cristiane T. Citadin, Jake T. Neumann, Donatella Pastore, Davide Lauro, David Della‐Morte, Hung Wen Lin   +12 more
openalex   +2 more sources

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats

, 2017
Elizabeth T. Nguyen, Joshua Streicher, Sarah Berman, Jody L. Caldwell, Valentina Ghisays, Christina M. Estrada, Aynara C. Wulsin, Matia B. Solomon   +7 more
openalex   +2 more sources

Glucocorticoid Secretion Inhibition [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Glucocorticoid Receptor Maintains Vasopressin Responses in Kidney Collecting Duct Cells [PDF]

, 2022
Hsiu-Hui Yang, Shih-Han Su, Cheng-Hsuan Ho, Ai-Hsin Yeh, Yi‐Jiun Lin, Ming‐Jiun Yu   +5 more
openalex   +1 more source